Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions and centers seeking to study genetic and environmental interactions on genomic variant impact. Eligible applicants are typically research institutions, universities, and established research centers with capacity to conduct genomic research and lead consortium-level work. The grant supports research investigating how genetic or environmental factors interact to modify variant effects beyond additive models. Applicants must be willing to participate in the IGVF Consortium and collaborate on shared resources, assays, and analysis strategies with other funded centers.
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Key dates
- Jun 6, 2025 Applications open
- Aug 22, 2025 Application deadline
- May 25, 2026 Award announced
- May 25, 2026 Project start
Program description
The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, centers funded through this initiative will propose a research framework to investigate whether interactions, with effects beyond additive, are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions. The rationale for this research is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding of Genome-wide Association Studies (GWAS), and improved polygenic scores. As IGVF Consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in 2025 with an expected application due date in 2025. This NOFO will utilize the UM1 activity code.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- Project Narrative
- Budget and Budget Justification
- Institutional Biosketches (PD/PI and key personnel)
- NIH Biographical Sketches
- Letters of Support from Consortium Partners
- Data Management and Sharing Plan
- Conflict of Interest Disclosure
Program contact
- 👤 Mike Pazin National Human Genome Research Institute (NHGRI)
- 📧 michael.pazin@nih.gov
- 📞 301-480-2629
Funding track record
Recent awards under CFDA 93.172 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$39,531,110
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$34,574,245
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$32,186,204
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$30,195,606
-
$26,495,937
-
$26,020,371
-
$24,964,130
-
$24,413,854
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$23,757,911
-
$22,977,417
Top States by Funding
- CA 19 awards $317.2M
- MA 16 awards $302.5M
- WA 9 awards $140.1M
- NY 6 awards $93.6M
- NC 5 awards $93.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.172). How funding has trended year over year.
| 2024 | $452,727,668 | |
| 2025 | $423,878,429 | |
| 2026 est. | $9,989,158 |
FAQ
Who can apply for this grant?
Research institutions and universities with capacity to conduct genomic research. Applicants must be able to lead consortium research and collaborate with other centers.
When is the deadline?
The application deadline is August 22, 2025. This is a fixed deadline, not rolling.
What type of research does this grant support?
Research studying how genetic and environmental interactions affect genomic variant impact. Focus is on non-additive interaction effects and understanding variant mechanisms.
Do I need to cost-share on this award?
No cost-sharing is required. Full eligible costs can be requested in your budget.
What is the funding amount?
Award amounts are not specified in the NOFO. Review the full funding opportunity notice when published for specific funding details and institutional limitations.
💡 Tips for applicants
- Emphasize your center's capacity for consortium-level collaboration and willingness to share resources with other funded teams. Address explicitly how you will coordinate with IGVF partners.
- Design a clear, testable research framework for investigating genomic variant interactions. Explain your experimental approach for testing interaction combinations.
- Include plans for making all consortium resources accessible to external users. Describe data management, sharing infrastructure, and user access strategies.
- Detail your expertise in genome-wide association studies (GWAS), polygenic scoring, and variant effect prediction. Highlight relevant preliminary data and previous consortium experience.
- Propose concrete mechanisms for coordinating assays, variants, cell types, and analysis strategies across consortium components. Show how your work integrates with broader consortium goals.
⚠️ Common mistakes
Failing to address consortium collaboration requirements and resource-sharing commitments adequately. Proposing research focused only on additive variant effects without clear interaction testing framework. Submitting without evidence of institutional capacity to manage complex multi-center coordination and data accessibility standards.
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