DoW Bone Marrow Failure, Investigator-Initiated Research Award
🏛 Defense Health Agency Contracting Activity - DHACA (DOD-AMRAA)
Can you apply?
This grant is for researchers investigating bone marrow failure (BMF) in humans. Eligible applicants include academic institutions, research centers, hospitals, and organizations with established research capacity. The program supports translational and clinical research using preclinical models, human data, anatomical substances, and human subjects. Studies must generate mature ideas with significant BMF research or patient care potential. Clinical trials are not supported. Preliminary data relevant to the proposed project is required.
Program description
Summary: Supports studies that further develop mature ideas, expand upon key discoveries, and have the potential to make significant advances in bone marrow (BMF) failure research and/or patient care. Investigator-Initiated Research Award (IIRA) applications may involve translational and clinical research including studies in preclinical models, research with human data and/or anatomical substances, and research with human subjects, as well as correlative studies associated with a clinical trial(s); however, this award mechanism does not support clinical trials. IIRA applications may also support Investigational New Drug (IND)-enabling efforts such as lead compound characterization, and assessments of formulation and stability, absorption, distribution, metabolism and excretion, dose/response and toxicology.
Distinctive Features:
This funding mechanism allows for a partnering Principal Investigator (PI). Only the initiating PI will submit a pre-application, but both PIs will need to submit full applications. The partnering PI application is an abbreviated package specific to their distinct portion of the research project. Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.
This award mechanism requires preliminary data relevant to the proposed project. Applications can support clinical research studies; however, this mechanism does not allow clinical trials.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Federal application form)
- Project Narrative/Research Proposal
- Budget and Budget Justification
- Preliminary Data section
- Institutional Commitment letters (if applicable)
- CV or biographical sketches of key personnel
Program contact
- 👤 Christopher L Baker Grants Officer
- 📧 help@eBRAP.org
- 📞 3016192332
Funding track record
Recent awards under CFDA 12.420 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$2,265,729,366
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$800,631,761
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$74,531,880
-
$67,205,571
-
$53,846,370
-
$34,191,124
-
$24,907,742
-
$21,394,379
-
$19,100,256
-
$19,002,641
Top States by Funding
- MD 10 awards $3,150.1M
- NC 11 awards $132.3M
- FL 8 awards $99.8M
- CA 11 awards $99.3M
- TX 8 awards $76.5M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 12.420). How funding has trended year over year.
| 2024 | $1,483,968,520 | |
| 2025 | $1,201,153,417 |
FAQ
Who can be a principal investigator for this award?
Academic researchers, clinician-scientists, and established investigators from eligible institutions. A partnering PI is allowed, and both must submit full applications if partnering.
Can this award support clinical trials?
No. Clinical trials are not supported. However, clinical research studies and correlative studies associated with clinical trials are eligible.
What types of research does this award support?
Translational research, preclinical models, human subject research, IND-enabling studies, and lead compound characterization are all eligible.
Is preliminary data required?
Yes. Applications must include preliminary data relevant to the proposed project.
When is the deadline?
November 4, 2026. Check the DoD USAMRAA website for any updates or rolling deadlines.
💡 Tips for applicants
- Include preliminary data early in your proposal. Reviewers will assess feasibility based on existing results and methods.
- If partnering with a co-PI, clarify distinct roles and responsibilities. Both must submit full applications with separate budgets.
- Frame your research as advancing BMF patient care or knowledge. Connect to clinical relevance even for preclinical studies.
- Address IND-enabling work clearly if applicable. Specify which studies support regulatory pathway progress.
- Budget for appropriate infrastructure and personnel. DoD reviewers expect detailed justification for all research costs.
⚠️ Common mistakes
Submitting without preliminary data or underselling existing results. Proposing clinical trials (not eligible). Failing to clearly define each partnering PI's distinct contribution and budget.
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