Dementia Care and Caregiver Support Intervention Research – Stages II – V
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for researchers and research institutions with strong expertise in behavioral intervention development for people with Alzheimer's disease and related dementias (AD/ADRD).
Eligible applicants must have completed NIH Stage I activities and be ready to conduct Stage II-V research. The intervention must be in developed and testable form. Cost sharing is not required.
This funding supports a two-year planning phase with potential transition to clinical trials if milestones are met. Applications are not currently being solicited; this is advance notice only.
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Key dates
- Jun 27, 2025 Applications open
- Feb 16, 2026 Application deadline
- Dec 1, 2026 Award announced
- Dec 1, 2026 Project start
Program description
The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to invite NIH Stage Model Stage II-V research applications focused on the development of behavioral interventions for persons living with Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) and/or their care partners or caregivers. Awards made through this NOFO will support a milestone-driven planning phase for up to two years, with possible transition to a clinical trial phase pending successful completion of the required milestones. The intervention(s) to be tested as part of this NOFO are expected to be in a developed and testable form, with Stage I activities completed prior to the proposed work. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the R61/R33 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- County Government
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&D)
- Project Narrative (research strategy)
- Budget and Budget Narrative
- Biosketches (key personnel)
- NIH Stage Model documentation (Stage I completion)
Program contact
- 👤 Melissa Riddle, Ph.D. National Institute on Aging (NIA)
- 📧 melissa-riddle@nih.gov
- 📞 301-480-6761
Funding track record
Recent awards under CFDA 93.866 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$463,372,200
-
$172,327,224
-
$115,145,694
-
$99,649,073
-
$93,275,174
-
$82,572,681
-
$81,344,612
-
$78,657,309
-
$75,825,492
-
$75,398,895
Top States by Funding
- CA 10 awards $633.7M
- MI 2 awards $511.9M
- MO 8 awards $453.5M
- IN 4 awards $303.9M
- PA 6 awards $298.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.866). How funding has trended year over year.
| 2024 | $3,746,886,731 | |
| 2025 | $3,777,464,644 | |
| 2026 est. | $261,814,471 |
FAQ
Who can apply for this grant?
Researchers and institutions with Stage I work completed who want to test behavioral interventions for AD/ADRD patients or caregivers. You must be ready to move to Stage II-V research under the NIH Stage Model.
What types of interventions does this support?
Behavioral interventions for persons with dementia and/or their caregivers. The intervention must be developed and testable, not in early conceptual stages.
What is the funding structure?
Up to two years of planning/validation funding with possible transition to a clinical trial phase upon successful milestone completion. The R61/R33 activity code is used.
When is the deadline?
Applications are not currently being solicited. This NOFO will open in the future; watch NIA announcements for the formal opening date.
Is cost sharing required?
No, cost sharing is not required for this grant.
💡 Tips for applicants
- Start planning your Stage II activities now. Ensure your Stage I work is thoroughly documented and published or presented to demonstrate readiness.
- Identify strong collaborators with caregiving expertise. Interventions must address real needs of both patients and care partners.
- Plan realistic milestones for the two-year planning phase. The transition to clinical trials depends on meeting these benchmarks.
- Build relationships with patient and caregiver advisory boards early. Their input strengthens both research design and likelihood of adoption.
- Review the NIH Stage Model framework carefully. Your application must clearly align with Stage II-V activities, not earlier development work.
⚠️ Common mistakes
Applying without completed Stage I work. Proposing interventions that are still in conceptual or early development stages. Underestimating the importance of caregiver input and engagement in intervention design.
Similar grants
- CLOSED Dementia Care and Caregiver Support Intervention Research – Stage I Only — National Institutes of Health
- CLOSED Early- and Late-Stage Clinical Trials for the Spectrum of Alzheimer’s Disease/Alzheimer’s Disease-Related Dementias and Age-Related Cognitive Decline — National Institutes of Health
- CLOSED Research Project Cooperative Agreements in Aging and/or Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) Research — National Institutes of Health
- CLOSED Specialized Center Cooperative Agreements in Aging and/or Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD) Research — National Institutes of Health
- OPEN NIA Expanding Research in AD/ADRD (ERA) Postbaccalaureate Research Education Program (R25 Independent Clinical Trial Not Allowed) — National Institutes of Health