Centers for Structural Biology of HIV and other Infectious Diseases
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for established research institutions seeking to create or enhance structural biology research centers focused on HIV and other infectious diseases.
Eligible applicants include major research universities, medical institutions, and research-intensive nonprofits with strong structural biology capabilities. Institutions must demonstrate existing or planned expertise in structural techniques like X-ray crystallography, cryo-EM, or computational modeling.
The program supports construction of research centers, staffing, equipment, and collaborative infrastructure. Centers may focus on structural characterization of viral or bacterial pathogens and host-pathogen interactions.
Geographic scope is nationwide. Priority may be given to institutions with existing NIH research portfolios and institutional commitment to infectious disease research.
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Key dates
- Dec 22, 2025 Applications open
- Dec 18, 2026 Application deadline in 155 days
- Jul 1, 2027 Award announced
- Jul 1, 2027 Project start
Program description
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting the Centers for Structural Biology of HIV and other Infectious Diseases. This solicitation will support multidisciplinary groups of scientists to determine the 3-dimensional structures of molecules and molecular complexes involved in priority infectious diseases. The effort focuses on exploring biomolecular complexes that can be targeted to make new medicines and tests to prevent or treat infections and improve human health. The centers will drive cutting-edge research and development of structural biology technologies, including high-resolution 3D structural analyses, computational molecular dynamics, functional and mechanistic characterization at the molecular and cellular level, visualization at the atomic level of molecular complexes in cells and tissues, and advanced structure-guided design of molecules to combat infectious diseases. The centers will maximize use of common resources, establish broad collaborations, and mentor future structural biology researchers. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 and SF-424 (R&R)
- Project Narrative and Research Strategy
- Budget and Budget Justification
- Institutional Commitments and Letters of Support
- Biosketches of Key Personnel
- Facilities and Resources Documentation
Program contact
- 👤 Division of AIDS
- 📧 sciops@niaid.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$246,626,852
-
$201,437,825
-
$185,816,804
-
$180,737,624
-
$136,265,880
-
$116,817,868
-
$93,394,862
-
$89,845,851
-
$74,456,241
-
$72,987,380
Top States by Funding
- CA 8 awards $696.2M
- MA 6 awards $602.8M
- NY 6 awards $335.0M
- TX 3 awards $280.9M
- GA 5 awards $257.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
Who can apply to this grant?
Universities, medical centers, and research nonprofits with demonstrated structural biology capacity. Your institution needs strong research infrastructure and leadership.
What activities does this funding support?
Research center development, new equipment, staffing, and collaborative research on structural biology of infectious disease pathogens. Training components are common.
Is this a one-time award or multi-year funding?
NIH center grants are typically 5-year awards with renewal options. Check the specific RFP for exact terms.
What makes an application competitive?
Strong preliminary data, institutional commitment, experienced leadership, and clear research innovation. Collaboration with other institutions strengthens proposals.
What's the typical funding range?
Structural biology centers typically receive $500K-$2M+ annually depending on scope. Review the RFP for specific budget guidelines.
💡 Tips for applicants
- Establish strong institutional commitment early. Leadership buy-in and resources are essential.
- Build a multidisciplinary team with complementary expertise in different structural methods.
- Include letters of support from collaborating institutions or international partners.
- Emphasize the public health relevance of your research focus within infectious disease.
- Detail your research infrastructure, equipment, and plans for training the next generation.
⚠️ Common mistakes
Weak institutional support or lack of demonstrated research capacity in structural biology methods. Unclear research focus or poorly defined center mission and goals. Insufficient detail on how your center will advance the field beyond single-PI work.
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