Special Projects of National Significance

SPNS
CFDA 93.928 Active Grant Cooperative Agreement

Program Funding

Annual program obligations reported to SAM.gov.

Latest annual funding
$19.4M FY2025
$21.7M
FY24
$19.4M
FY25

Who has received this funding

Organizations awarded under CFDA 93.928 (USAspending.gov).

Funded Projects

Examples of what this program has supported.

FY2025 The Ryan White HIV/AIDS Program is at the forefront of efforts to Make America Healthy Again and the Ending the HIV Epidemic in the U.S. (EHE) initiative. New data highlight key milestones, including:

Nearly 602,000 people with HIV in the U.S. received life-saving care, medication, and essential support services through the Ryan White HIV/AIDS Program, representing over half of those with diagnosed HIV in the U.S. This is an increase of nearly 26,000 clients.

More than 91% of Ryan White HIV/AIDS Program patients receiving HIV medical care were virally suppressed in 2024. This is up from 69.5% of patients virally suppressed in 2010 and significantly higher than the 67.2% virally suppressed nationally among all people with diagnosed HIV.

More than 47% of Ryan White HIV/AIDS Program clients are aged 50 years and older, demonstrating the program’s success in supporting older clients.
FY2026 The Ryan White HIV/AIDS Program is at the forefront of efforts to Make America Healthy Again and the Ending the HIV Epidemic in the U.S. (EHE) initiative. New data highlight key milestones, including:

Nearly 602,000 people with HIV in the U.S. received life-saving care, medication, and essential support services through the Ryan White HIV/AIDS Program, representing over half of those with diagnosed HIV in the U.S. This is an increase of nearly 26,000 clients.

More than 91% of Ryan White HIV/AIDS Program patients receiving HIV medical care were virally suppressed in 2024. This is up from 69.5% of patients virally suppressed in 2010 and significantly higher than the 67.2% virally suppressed nationally among all people with diagnosed HIV.

More than 47% of Ryan White HIV/AIDS Program clients are aged 50 years and older, demonstrating the program’s success in supporting older clients.

Program Objective

The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part F Special Projects of National Significance (SPNS) Program is to support the development of innovative models of HIV care and treatment to quickly respond to emerging needs of RWHAP clients. Through its demonstration, implementation, and health information technology projects, SPNS uses implementation science to evaluate the design, implementation, use, cost, and health-related outcomes of treatment strategies while promoting the dissemination and replication of successful interventions in the RWHAP. This unique program advances knowledge and skills in the delivery of health care, support services, and data integration to serve RWHAP priority populations. Through these special projects, RWHAP SPNS recipients implement a variety of interventions that advance public health knowledge and help to achieve the goal of ending the HIV epidemic in the United States.

Eligibility

Eligible Applicants

  • U.S. State Government
  • Local
  • Federally Recognized Tribal Government
  • U.S. Territory Government
  • Tribal Government (other)
  • Other

Academic institutions, non-profit organizations including faith-based organizations, and those eligible for funding under Parts A-D authorized by Title XXVI of the Public Health Service (PHS) Act. Additionally, federally recognized Indian Tribal Governments and tribal organizations are also eligible to apply for these funds.

Beneficiaries

  • Other

Individuals with HIV.

How to Apply

Award Procedure

All qualified applications will be forwarded to an objective review committee. Based on the recommendations of the objective review committee, the HRSA program official with delegated authority is responsible for final selection and funding decisions. Notification is made in writing by a Notice of Award (NOA).

Approximately 6 months.

Program details & compliance

Description

The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part F Special Projects of National Significance (SPNS) Program is to support the development of innovative models of HIV care and treatment to quickly respond to emerging needs of RWHAP clients. Through its demonstration, implementation, and health information technology projects, SPNS uses implementation science to evaluate the design, implementation, use, cost, and health-related outcomes of treatment strategies while promoting the dissemination and replication of successful interventions in the RWHAP. This unique program advances knowledge and skills in the delivery of health care, support services, and data integration to serve RWHAP priority populations. Through these special projects, RWHAP SPNS recipients implement a variety of interventions that advance public health knowledge and help to achieve the goal of ending the HIV epidemic in the United States.

Mission Categories

Primary: Communicable Diseases

Other categories:
Health EducationPrevention and Control (includes Suicide Prevention)

Use of Funds

Allowed Uses

Proposals are expected to adequately define and justify the needs, innovative nature, and evaluation methodology of the proposed model of services. Funds shall be used to create and/or evaluate innovative models of HIV care, services, capacity development initiatives, and health information and technology data systems that would likely not exist nor be evaluated without RWHAP Part F SPNS Program support, or that would extend the care model to previously underserved or uninsured populations.

Restrictions

Funds may not be used for: • charges that are billable to third party payers (e.g., private health insurance, prepaid health plans, Medicaid, Medicare); • purchasing or construction of new facilities or capital improvements to existing facilities; • purchasing or improving land; • international travel; • cash payments to intended recipients of RWHAP services; • pre-exposure prophylaxis (PrEP); • non-occupational post-exposure prophylaxis (nPEP)

Funds may not be used for outreach programs that have HIV prevention education as their exclusive purpose, or broad-scope awareness activities about HIV services that target the general public.

Additionally, the purchase of sterile needles or syringes for the purposes of hypodermic injection of any illegal drug is not allowable. Some aspects of syringe services programs are allowable with HRSA's prior approval and in compliance with HHS and HRSA policy (see: https://www.hiv.gov/federal-response/policies-issues/syringe-services-programs).

Required Documentation

Applicants should review the individual HRSA Notice of Funding Opportunity (NOFO) issued under this assistance listing for any required proof or certifications which must be submitted prior to or simultaneous with submission of an application package. All HRSA awards are subject to the Uniform Administrative Requirements, Cost Principles, and Audit Requirements at 2 CFR 200 and modifications at 2 CFR 300., Subpart E - Cost Principles applies to this program.

Reporting & Compliance

Audit Required
Yes — Determined at Time of Award
Records Retention
3 years

Applicable 2 CFR 200 Subparts

  • Subpart B — General Provisions
  • Subpart C — Pre-Federal Award Requirements
  • Subpart D — Post-Federal Award Requirements
  • Subpart E — Cost Principles
  • Subpart F — Audit Requirements

Contacts

Michael Kharfen, Director, Division of Policy and Data — Special Projects of National Significance
301.945.5468
HIV/AIDS Bureau Health Resources and Services Administration, Rockville, MD 20857
Data from SAM.gov Federal Assistance Listings. Source published: 2026-01-12. Spec v2.0. Last synced: 2026-05-30 02:31:12.