Office of Science Financial Assistance Program

(Advanced Scientific Computing Research (ASCR), Basic Energy Sciences (BES), Biological and Environmental Research (BER), Fusion Energy Sciences (FES), High Energy Physics (HEP), Nuclear Physics (NP), Workforce Development for Teachers and Scientists (WDTS), Small Business Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR) Program), Isotope R&D and Production (DOE IP), Accelerator R&D and Production (ARDAP))
CFDA 81.049 Active Project Grants (Cooperative Agreements)

Open Opportunities (5)

Live Grants.gov opportunities funded under this program — you can apply now.

Program Funding

Annual program obligations reported to SAM.gov.

Latest annual funding (estimated)
$1.7B FY2025
$1.15B
FY16
$1.13B
FY17
$1.33B
FY18
$1.26B
FY19
$1.35B
FY20
$1.37B
FY21
$1.53B
FY22
$1.72B
FY23
$1.55B
FY24*
$1.7B
FY25*
* estimated

Who has received this funding

Organizations awarded under CFDA 81.049 (USAspending.gov).

Program Objective

SC is the Nation’s largest Federal sponsor of basic research in the physical sciences and the lead Federal agency supporting fundamental scientific research for our Nation’s energy future. SC is an established leader of the U.S. scientific discovery and innovation enterprise. Over the decades, SC investments and accomplishments in basic research and enabling research capabilities have provided the foundations for new technologies, businesses, and industries, making significant contributions to our nation’s economy, national security, and quality of life. Additional descriptions of recent science discoveries can
be found at https://science.osti.gov/Science-Features/Science-Highlights.

SC accomplishes its mission and advances national goals by supporting:
- Science for energy, economic and national security―building a foundation of scientific and technical knowledge to spur discoveries and innovations for advancing the Department’s mission. SC supports a wide range of funding modalities from single principal investigators to large team-based activities to engage in fundamental research on energy production, conversion, storage, transmission, and use, and on our understanding of the earth systems.
- The frontiers of science—exploring nature’s mysteries from the study of fundamental subatomic particles, atoms, and molecules that are the building blocks of the materials of our universe and everything in it to the DNA, proteins, and cells that are the building blocks of life. Each of the programs in SC supports research probing the most fundamental disciplinary questions.
- The 21st Century tools of science—providing the nation’s researchers with 28 state-of-the-art national scientific user
facilities, the most advanced tools of modern science, propelling the U.S. to the forefront of science, technology
development, and deployment through innovation.

Eligibility

Eligible Applicants

  • State governments
  • Local governments
  • Sponsored organization
  • Public nonprofits
  • Other public organizations
  • Federally recognized tribes
  • U.S. territories (incl. universities)
  • Non-government (general)
  • Individuals / families
  • Minority groups
  • Small businesses
  • For-profit organizations
  • Private nonprofits
  • Quasi-public nonprofits
  • Other private organizations
  • Anyone / general public
  • Native American organizations

Except where a program solicitation establishes more restrictive eligibility criteria, individuals and organizations in the following categories may submit proposals: Institutions of higher education; National Laboratories; Nonprofit and for-profit private entities; State and local governments; and consortia of entities described above.

How to Apply

Application Procedure

The Office of Science utilizes an automated system, the Portfolio Analysis and Management System (PAMS), to manage the grants applications and award process. An application will automatically transfer from Grants.gov into PAMS for processing. In order to manage the application in PAMS, applicants must register at https://pamspublic.science.energy.gov.

Award Procedure

After selections, DOE may negotiate a financial assistance award with the selected applicant. Only a DOE Contracting Officer is authorized to approve financial assistance agreement.

Normally, 6 months from receipt of grant application. Every notice of funding opportunity published at https://www.grants.gov will detail its anticipated notification schedule.

Program details & compliance

Description

SC’s basic research portfolio, which includes extramural grants and contracts supporting nearly 29,000 researchers located at over 300 institutions and the 17 DOE national laboratories, spanning all fifty states and the District of Columbia. Our researchers advance our understanding of the natural universe and create the discoveries that can be exploited in numerous fields.

Use of Funds

Allowed Uses

See information at https://science.osti.gov/Science-Features/Science-Highlights for features about our research activities. A full listing of past and current awards is available at https://pamspublic.science.energy.gov/WebPAMSExternal/interface/awards/AwardSearchExternal.aspx

Required Documentation

Applications must be signed electronically by an official authorized to commit the institution or organization in business and financial affairs and who can commit the organization to certain National Policy Assurances to be incorporated as award terms in effect on date of award at https://www.nsf.gov/awards/managing/rtc.jsp.

Reporting & Compliance

Audit Required
Yes

Applicable 2 CFR 200 Subparts

  • Subpart B — General Provisions
  • Subpart C — Pre-Federal Award Requirements
  • Subpart D — Post-Federal Award Requirements
  • Subpart E — Cost Principles
  • Subpart F — Audit Requirements

Contacts

Michael S. Zarkin — Director, Office of Grants and Contracts Support
301-903-4946
19901 Germantown Road, Germantown, MD 20874
Data from SAM.gov Federal Assistance Listings. Source published: 2024-11-26. Spec v1.0. Last synced: 2026-06-01 05:54:15.