Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Infrastructure – Clinical Enrollment Hubs
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 18, 2026
Can you apply?
This grant is for institutions applying to lead clinical enrollment hubs within the SIREN clinical trials network. Organizations must have capacity to support neurological and cardiovascular emergency research in pre-hospital or emergency department settings. Eligible applicants typically include medical centers, hospital networks, and research institutions with emergency medicine infrastructure. Multi-institutional collaborations are encouraged and may be required to meet network goals.
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Key dates
- Aug 13, 2026 Applications open
- Mar 4, 2027 Application deadline in 136 days
- Dec 7, 2027 Award announced
- Mar 4, 2028 Project start
Program description
The National Institute of Neurological Disorders and Stroke (NINDS), in conjunction with The National Heart, Lung and Blood Institute (NHLBI), at the National Institutes of Health (NIH) seek to continue to support the Infrastructure for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The program will encourage applications for network clinical enrollment hubs to support the NIH SIREN clinical trial network. The SIREN Network performs clinical trials that impact the care of individuals with a non-stroke neurological and cardiovascular emergency in the pre-hospital or emergency department setting. The goal of SIREN is to improve the outcomes by identifying effective treatments given in the earliest stages of care.
Applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive applications for centers.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Application for Federal Assistance)
- Project Narrative/Technical Approach
- Budget and Budget Justification
- Institutional Biosketches (Key Personnel)
- Letters of Institutional Support
- Evidence of IRB and regulatory compliance capabilities
- Documentation of emergency medicine research infrastructure
Program contact
- 👤 NINDS Department of Emergency Medicine
- 📧 NINDS_SIREN@ninds.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.853 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$56,262,774
-
$45,083,283
-
$43,730,658
-
$38,186,781
-
$37,769,493
-
$35,655,349
-
$35,655,116
-
$34,183,297
-
$32,294,153
-
$32,164,022
Top States by Funding
- MA 7 awards $186.3M
- CA 6 awards $163.5M
- FL 4 awards $121.0M
- OH 4 awards $112.5M
- NY 3 awards $91.7M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.853). How funding has trended year over year.
| 2024 | $2,362,835,459 | |
| 2025 | $2,345,500,401 |
FAQ
Who can apply for this grant?
Medical centers, hospitals, and research institutions with emergency medicine departments and research infrastructure. Multi-institutional consortiums are encouraged.
What is the deadline?
March 4, 2027. This is a fixed deadline, not rolling.
What types of trials does SIREN support?
Clinical trials for non-stroke neurological and cardiovascular emergencies in pre-hospital and emergency department settings.
How competitive is this funding?
This is a selective infrastructure program supporting specific network hubs. Strong preliminary data and institutional commitment are important.
What award amounts should I expect?
Award amounts vary by hub role and scope. Contact NINDS or NHLBI for specific funding levels for this cycle.
💡 Tips for applicants
- Establish collaborative relationships early with other potential hub sites and NINDS/NHLBI program officers before the deadline.
- Demonstrate existing emergency medicine research infrastructure and capacity for multi-site coordination.
- Clearly describe your institution's role in the broader SIREN network ecosystem.
- Include letters of support from partner institutions and key stakeholders in emergency care.
- Highlight experience with rapid patient enrollment and pre-hospital or emergency department recruitment.
⚠️ Common mistakes
Unclear network coordination plan or insufficient detail on how your hub integrates with the national SIREN infrastructure. Lack of demonstrated emergency medicine research experience or insufficient institutional commitment to the network. Vague enrollment strategies or unrealistic patient volume projections for neurological and cardiovascular emergencies.
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