Special Projects of Regional and National Significance

CFDA 93.110 Active Grant Cooperative Agreement

Open Opportunities (5)

Live Grants.gov opportunities funded under this program — you can apply now.

Program Funding

Annual program obligations reported to SAM.gov.

Latest annual funding (estimated)
$185.7M FY2026
$274.5M
FY24
$265.7M
FY25
$185.7M
FY26*
* estimated

Who has received this funding

Organizations awarded under CFDA 93.110 (USAspending.gov).

Funded Projects

Examples of what this program has supported.

FY2025 HRSA advanced maternal and child health outcomes by strengthening community-driven, data-informed systems of care across the country. Through the Fetal Alcohol Spectrum Disorders (FASD) program, HRSA implemented pediatric and prenatal Extension for Community Healthcare Outcomes (ECHO) learning collaboratives and clinical trainings to reduce prenatal alcohol exposure, engaging urban, rural, and Tribal clinics and health care teams. These efforts reached more than 300 providers and over 3,000 patients, with updated curricula and tested participant surveys supporting continuous quality improvement. Complementing this work, the State Maternal Health Innovation (MHI) program funded 42 states and the District of Columbia to address maternal mortality and severe maternal morbidity among populations at greatest risk. All award recipients established multidisciplinary maternal health task forces—bringing together Title V programs, Perinatal Quality Collaboratives, Medicaid, community-based organizations, clinicians, and individuals with lived experience—to drive innovation in workforce development, systems change, data enhancement, and community engagement. In parallel, the Children’s Safety Network (CSN), funded by SPRANS, strengthened state and jurisdictional capacity to use data to prevent fatal and serious injuries among children and youth, including suicide. Together, these coordinated investments enhanced community partnerships and public awareness, accelerated dissemination of evidence, improved consistency and quality of care across settings, and better aligned maternal and child health programs with local capacity and practice.

Program Objective

The Special Projects of Regional and National Significance Program (SPRANS) carries out maternal and child health (MCH) projects to support training and research; oral health integration; genetic disease testing, counseling, and information development and dissemination programs; newborn screening for sickle cell anemia and other genetic disorders; and comprehensive hemophilia diagnostic and treatment centers. The Supporting Fetal Alcohol Spectrum Disorder (FASD) Screening and Intervention helps reduce alcohol use during pregnancy and improves outcomes for children with FASD nationwide, especially in communities where there is a high rate of binge drinking during pregnancy, including rural areas and medically underserved communities. The program focuses on educating primary care providers and increasing the use of screening, intervention, and referral processes for high-risk pregnancies. The State Maternal Health Innovation program creates state-led maternal health task forces to bring together the voices of key leaders, and pregnant and postpartum individuals using state-specific maternal health data to develop and implement innovative approaches to address the most pressing maternal health needs and disparities. State approaches include strengthening partnerships and collaborations, improving state-level data surveillance on maternal mortality and severe maternal morbidity, and promoting and executing innovation in maternal health service delivery. The MCH Research Portfolio includes the MCH Research Consortium, Maternal Health Research Collaborative for Minority-Serving Institutions, MCH Research Network, and MCH Field-Initiated Innovative Research Studies programs. The research portfolio advances maternal and child health by generating and testing innovative, real-world approaches to improve population-level outcomes. The program addresses critical evidence gaps through the development of research infrastructure and the conduct of rigorous, community-engaged research in close partnership with families and other stakeholders. MCH RNs focus on collaborative, interdisciplinary. The Children’s Safety Network (CSN) purpose is to increase the capacity of Title V agencies to adopt and implement evidence-based child and adolescent safety programs, practices, and policies, with a specific focus on injury and violence-related to Title V performance and outcome measures, such as injury hospitalizations, bullying, safe sleep, and suicide, as well as leading causes of injury-related deaths among children and adolescents (e.g., motor vehicle crashes, firearms, and poisonings).

Eligibility

Eligible Applicants

  • U.S. State Government
  • Local
  • Nonprofit Organization
  • Federally Recognized Tribal Government
  • Tribal Government (other)
  • U.S. Territory Government
  • Other

Training grants may be made to public or private nonprofit institutions of higher learning. Research grants may be made to public or private nonprofit institutions of higher learning and public or private nonprofit private agencies and organizations engaged in research or in MCH or Children with Special Health Care Needs (CSHCN) programs. Any public or private entity is eligible for hemophilia, genetics, and environmental health grants and other special project grants, including SPRANS and CISS. Eligible entities for the Supporting Fetal Alcohol Spectrum Disorders Screening and Intervention program are any domestic public or private entity, including Indian tribes or tribal organizations (as those terms are defined at 25 U.S.C. 450b). See 42 CFR § 51a.3(a), and domestic faith-based and community-based organizations. Eligible entities for the State Maternal Health Innovation program include any domestic public or private entity, including Indian tribes or tribal organizations, as well as domestic faith-based and community-based organizations. Eligible entities for the Integrated Maternal Health Services program include any domestic public or private entity, including Indian tribes or tribal organizations, as well as domestic faith-based and community-based organizations.

Beneficiaries

  • Health Professional
  • Infant and Toddler (0–3)
  • Other
  • Young Child (4–9)

Specialized group (e.g. health professionals, students, veterans), Health Professional, Student/Trainee, Women, Infant (0-5), Child (6-15)

For training grants: (1) Trainees in the health professions related to MCH; and (2) mothers and children who receive services through training programs. For research grants: public or private nonprofit agencies and organizations engaged in research in MCH or CSHCN programs. For hemophilia, sickle cell, thalassemia, genetics, newborn screening, environmental health, and other special projects: (1) Public or private agencies, organizations and institutions; and (2) mothers and children, and individuals with genetic conditions (any age) who receive services through the programs.

How to Apply

Award Procedure

All qualified applications will be forwarded to an objective review committee. Based on the recommendations of the objective review committee, the HRSA program official with delegated authority is responsible for final selection and funding decisions. Notification is made in writing by a Notice of Award.

Decision Timeline

  • Approval: From 120 to 180 days

Final decisions are made 4 to 6 months after receipt of applications.

Program details & compliance

Description

The Special Projects of Regional and National Significance Program (SPRANS) carries out maternal and child health (MCH) projects to support training and research; oral health integration; genetic disease testing, counseling, and information development and dissemination programs; newborn screening for sickle cell anemia and other genetic disorders; and comprehensive hemophilia diagnostic and treatment centers. The Supporting Fetal Alcohol Spectrum Disorder (FASD) Screening and Intervention helps reduce alcohol use during pregnancy and improves outcomes for children with FASD nationwide, especially in communities where there is a high rate of binge drinking during pregnancy, including rural areas and medically underserved communities. The program focuses on educating primary care providers and increasing the use of screening, intervention, and referral processes for high-risk pregnancies. The State Maternal Health Innovation program creates state-led maternal health task forces to bring together the voices of key leaders, and pregnant and postpartum individuals using state-specific maternal health data to develop and implement innovative approaches to address the most pressing maternal health needs and disparities. State approaches include strengthening partnerships and collaborations, improving state-level data surveillance on maternal mortality and severe maternal morbidity, and promoting and executing innovation in maternal health service delivery. The MCH Research Portfolio includes the MCH Research Consortium, Maternal Health Research Collaborative for Minority-Serving Institutions, MCH Research Network, and MCH Field-Initiated Innovative Research Studies programs. The research portfolio advances maternal and child health by generating and testing innovative, real-world approaches to improve population-level outcomes. The program addresses critical evidence gaps through the development of research infrastructure and the conduct of rigorous, community-engaged research in close partnership with families and other stakeholders. MCH RNs focus on collaborative, interdisciplinary. The Children’s Safety Network (CSN) purpose is to increase the capacity of Title V agencies to adopt and implement evidence-based child and adolescent safety programs, practices, and policies, with a specific focus on injury and violence-related to Title V performance and outcome measures, such as injury hospitalizations, bullying, safe sleep, and suicide, as well as leading causes of injury-related deaths among children and adolescents (e.g., motor vehicle crashes, firearms, and poisonings).

Mission Categories

Primary: Maternity, Infants, Children

Other categories:
General Health and Medical

Use of Funds

Allowed Uses

Training grants are made to institutions of higher learning for training personnel for health care and related services for mothers and children. Research grants are for the purpose of research activities which show promise of a substantial contribution to the advancement of maternal and child health (MCH) services. Technical assistance grants support the effective and accurate use of data and evidence to support program development and implementation as well as performance measurement and evaluation. Genetic grants are for genetic disease testing, counseling and information development and dissemination. Hemophilia grants are for the support of centers which provide hemophilia diagnostic and treatment services. Sickle cell disease grants are made to support follow up for infants with sickle cell identified through newborn screening. Environmental health grants are made to decrease maternal and child morbidity and mortality associated with pre-and post-natal environmental exposures. Other special project grants are designed to support activities of a demonstration nature, which are designed to improve services for mothers and children.

Restrictions

Indirect costs that are allowed for administrative costs incurred as a result of the training grants project, are limited to 8 percent of direct costs.

Required Documentation

Applicants should review the individual HRSA notice of funding opportunity issued under this Assistance Listing for any required proof or certifications which must be submitted prior to or simultaneous with submission of an application package.

2 CFR 200, Subpart E - Cost Principles applies to this program.

Matching Requirements

Opportunities may include matching requirements. Please refer to the notice of funding opportunity.

Reporting & Compliance

Audit Required
Yes — Determined at Time of Award
Records Retention
3 years

Applicable 2 CFR 200 Subparts

  • Subpart B — General Provisions
  • Subpart C — Pre-Federal Award Requirements
  • Subpart D — Post-Federal Award Requirements
  • Subpart E — Cost Principles
  • Subpart F — Audit Requirements

Contacts

Eliza Heppner, Acting Associate Administrator for Maternal and Child Health
301-443-2170
5600 Fishers Lane, Rockville, MD 20857
Data from SAM.gov Federal Assistance Listings. Source published: 2026-02-03. Spec v2.0. Last synced: 2026-06-01 02:00:32.