Translational Transplantation Tolerance Cooperative Study Group
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for organizations pursuing translational research in transplant tolerance to reduce life-long immunosuppressive drug dependence. Eligible applicants typically include research institutions, academic medical centers, and hospitals with established transplant programs and research capacity. The program supports multi-center cooperative studies evaluating immune tolerance approaches in translationally relevant models. Applicants must have appropriate regulatory compliance and institutional infrastructure to conduct clinical translational research.
Not the right fit? Find grants for your organization in 5 questions →
Key dates
- Jun 24, 2026 Applications open
- May 21, 2027 Application deadline in 309 days
- May 1, 2028 Award announced
- May 1, 2028 Project start
Program description
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission through the support of the Translational Transplantation Tolerance Cooperative Study Group (TTTCSG) program. The overarching goal of this program is to facilitate clinical translation of safe and effective transplant tolerance regimens that achieve long-term graft survival without the need for life-long administration of immunosuppressive drugs. This program will enable establishment of a multi-center, cooperative program dedicated to developing, optimizing, and evaluating approaches to induce and maintain immune tolerance to allogeneic transplants, which will be tested in translationally relevant models. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Federal Application for Grants and Cooperative Agreements)
- Project Narrative / Research Plan
- Budget and Budget Justification
- Biographical Sketches of Key Personnel
- Institutional Review Board (IRB) or Ethics Committee Approval Letters
- Letters of Institutional Commitment from Partner Sites
- Data Management and Safety Monitoring Plan
Program contact
- 👤 Division of Allergy, Immunology, and Transplantation
- 📧 TTTCSGU19@mail.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$246,626,852
-
$201,437,825
-
$185,816,804
-
$180,737,624
-
$136,265,880
-
$116,817,868
-
$93,394,862
-
$89,845,851
-
$74,456,241
-
$72,987,380
Top States by Funding
- CA 8 awards $696.2M
- MA 6 awards $602.8M
- NY 6 awards $335.0M
- TX 3 awards $280.9M
- GA 5 awards $257.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
Who can apply for this grant?
Research institutions, academic medical centers, hospitals, and other entities with strong transplant research programs and clinical capacity. Lead organizations must demonstrate multi-center partnership capability.
What is the main goal of this program?
To develop and test transplant tolerance approaches that achieve long-term graft survival without life-long immunosuppressive drugs. The program emphasizes clinical translation of safe, effective regimens.
What types of projects are funded?
Multi-center cooperative studies that develop, optimize, and evaluate immune tolerance induction strategies. Projects must use translationally relevant models and have clear clinical applicability.
When is the deadline?
The fixed deadline is May 21, 2027. Check NIAID's website for any updates closer to the deadline.
What funding level should I expect?
The total program pool is $10.46 million. Individual award amounts are not specified; contact NIAID program staff for guidance on typical award sizes.
💡 Tips for applicants
- Emphasize multi-center partnerships early. NIAID values cooperative, coordinated research across multiple sites.
- Ground your approach in translational science. Show clear pathways from laboratory research to clinical application.
- Highlight how your protocol addresses unmet clinical needs. Explain why reducing immunosuppressive burden matters to transplant recipients.
- Build a strong team with transplant clinicians, immunologists, and statisticians. Interdisciplinary expertise strengthens competitiveness.
- Address regulatory and safety considerations explicitly. Document your institution's capacity for clinical-grade research and data management.
⚠️ Common mistakes
Weak multi-center coordination planning. Vague or overly basic science focus without clear clinical translation pathway. Underestimating regulatory and safety documentation requirements for translational work.
Similar grants
- OPEN Collaborative Network for Clinical Research on Immune Tolerance — National Institutes of Health
- OPEN Cooperative Program for Modeling Clinical Transplantation — National Institutes of Health
- OPEN Clinical Trials in Organ Transplantation in Children and Adults — National Institutes of Health
- OPEN Asthma and Allergic Diseases Cooperative Research Centers — National Institutes of Health
- OPEN Clinical Data, Safety and Statistical Centers (CDSSC) — National Institutes of Health