Cooperative Program for Modeling Clinical Transplantation
Can you apply?
This grant is for research organizations studying organ and tissue transplantation outcomes and clinical decision-making. Eligible applicants include academic medical centers, research institutions, and 501(c)(3) nonprofits with transplant research capacity. Priority may be given to collaborative, multi-site research projects examining transplant modeling, outcomes prediction, and clinical utility. The program supports research activities across all U.S. territories and internationally-affiliated institutions.
Key dates
- Apr 9, 2026 Applications open
- Oct 9, 2026 Application deadline in 118 days
- Jul 1, 2027 Award announced
- Jul 1, 2027 Project start
Program description
The National Institute of Allergy and Infectious Diseases (NIAID) will support its mission through the Cooperative Program for Modeling Clinical Transplantation. Advancements of new therapeutics and success in human solid organ transplantation will require innovative and clinically translatable in-vitro and in–vivo systems to model local and systemic immune responses. This program seeks applications including new approach methods (NAMs) and/or refined mouse models that together will promote translation of new therapies to clinical practice. Potential NAMs include immune-competent microphysiological systems, organoids, ex-vivo perfused human organs, precision-cut tissue slices, and computational systems biology models. Applicants must propose models designed to overcome known obstacles to clinical translation in existing NAMS and/or mouse models, reduce reliance on nonhuman primates, and demonstrate relevance to clinical outcomes. Emphasis on data sharing will facilitate reproducibility and establishment of standards and best practices to achieve the program goals. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Application for Federal Assistance
- Research Project Narrative
- Detailed Budget and Budget Justification
- Biographical Sketches (Key Personnel)
- Institutional Support Letters
- Letters of Clinical Partnership/Collaboration
- Data Management and Sharing Plan
- Timeline and Milestones
Program contact
- 👤 National Institute of Allergy and Infectious Diseases (NIAID)
- 📧 CPMCT_U01@mail.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$438,527,853
-
$246,626,852
-
$204,359,786
-
$201,437,825
-
$200,221,259
-
$185,816,804
-
$180,737,624
-
$136,265,880
-
$116,817,868
-
$99,478,296
Top States by Funding
- CA 10 awards $818.8M
- WA 3 awards $684.0M
- MA 6 awards $602.8M
- NC 3 awards $446.4M
- NY 7 awards $375.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
Who can apply for this grant?
Academic medical centers, universities, and 501(c)(3) research institutions are eligible. Your organization must have institutional support and transplant research infrastructure.
What types of research does this program fund?
The program supports clinical transplantation modeling, outcomes prediction, and decision support tools. It also funds feasibility studies and validation of transplant-related research models.
Is there a funding cap for awards?
Funding levels vary by project scope. Typically, NIH research grants range widely depending on complexity and duration of the research proposed.
How competitive is this program?
NIH grants are highly competitive. Strong preliminary data, experienced teams, and multi-site collaboration strengthen applications significantly.
What is the timeline for application and funding?
Applications typically open in spring. Review periods take 3-6 months after submission. Funding usually begins 6-9 months after award notification.
💡 Tips for applicants
- Start with strong preliminary data showing feasibility of your modeling approach or clinical application. NIH reviewers expect evidence of scientific rigor.
- Build collaborative teams including transplant clinicians and biostatisticians. Multi-institutional partnerships often score better than single-site proposals.
- Align your research question directly to unmet clinical needs in transplantation. Explain how your model improves patient outcomes or clinical decision-making.
- Budget realistically for personnel, data infrastructure, and validation studies. Underestimating costs causes approval delays and credibility issues.
- Submit letters of institutional support and clinical partnerships early. Show that transplant centers are committed to using your model or tools.
⚠️ Common mistakes
Proposals lack preliminary data or feasibility evidence. Reviewers reject weak proof-of-concept submissions. Applicants propose modeling without clear clinical validation or utility pathway. Teams underestimate resources needed for multi-site coordination and data management.
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