Childhood Asthma in Urban Settings Clinical Research Network
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions and clinical research organizations studying asthma prevention and treatment in disadvantaged pediatric populations. Eligible applicants typically include universities, medical centers, and established clinical research networks with expertise in pediatric asthma. The grant supports multi-site clinical studies and trials across urban settings. Activities must focus on asthma prevention strategies, treatment targets, and disease mechanism research in economically disadvantaged children.
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Key dates
- Jun 24, 2026 Applications open
- May 28, 2027 Application deadline in 316 days
- Apr 1, 2028 Award announced
- Apr 1, 2028 Project start
Program description
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission through the continued support of the Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) network. The CAUSE network will support multi-site clinical studies and trials on the prevention and treatment of asthma in economically disadvantaged pediatric populations where disease burden is high. The objectives of the CAUSE network are to develop and test innovative hypotheses and strategies for asthma prevention; identify/test new treatment targets (including targets for intervention based on mechanisms of type 2 low asthma); and continue to explore the risk relationship between upper and lower airway. Using systems biology approaches, CAUSE will continue to identify disease endotypes that may be suitable targets for existing and novel therapeutic modalities. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Community Health Center
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 and SF-424 R&R forms
- Project Narrative and Research Strategy
- Budget and Budget Justification
- Letters of Support from clinical sites
- Institutional Biosafety Committee approval (if applicable)
- Institutional Review Board approval (if applicable)
- Curriculum Vitae for key personnel
Program contact
- 👤 Division of Allergy, Immunology, and Transplantation CAUSE Program Group
- 📧 CAUSE_NOFO@MAIL.NIH.GOV
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$246,626,852
-
$201,437,825
-
$185,816,804
-
$180,737,624
-
$136,265,880
-
$116,817,868
-
$93,394,862
-
$89,845,851
-
$74,456,241
-
$72,987,380
Top States by Funding
- CA 8 awards $696.2M
- MA 6 awards $602.8M
- NY 6 awards $335.0M
- TX 3 awards $280.9M
- GA 5 awards $257.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
Who can apply for this grant?
Research institutions, universities, medical centers, and clinical research networks with capacity to conduct multi-site studies. Prior experience with pediatric asthma research and access to disadvantaged urban populations strengthens applications.
What is the deadline?
The fixed deadline is May 28, 2027. Plan to submit well before this date.
What activities are supported?
Clinical studies on asthma prevention, new treatment targets, mechanisms of type 2 low asthma, and risk relationships between upper and lower airway disease.
How competitive is this funding?
This is a highly competitive program from NIAID. Applications must demonstrate innovative hypotheses and strong preliminary data to be competitive.
What is the funding range?
Award amounts are not specified in the announcement. Contact the program officer for typical funding levels for your proposed scope.
💡 Tips for applicants
- Build partnerships with clinical sites in underserved urban communities early. Multi-site networks are essential for this funding.
- Use systems biology approaches to identify disease endotypes. This aligns directly with NIAID priorities.
- Clearly articulate how your study targets economically disadvantaged pediatric populations specifically.
- Engage community partners and patient stakeholders in study design. This strengthens cultural relevance and feasibility.
- Work with the NIAID program officer before submission. Early feedback significantly improves competitiveness.
⚠️ Common mistakes
Failing to address how your research specifically targets disadvantaged populations. Submitting single-site studies instead of multi-site networks. Underestimating the clinical infrastructure needed to conduct rigorous multi-site trials.
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