Forecast to Publish a Notice of Funding Opportunity Announcement for Addressing Determinants of Health Disparities Among Rural Populations (R01 – Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research organizations studying health disparities in rural populations. R01 grants typically support independent research projects by experienced investigators at colleges, universities, hospitals, and other research institutions. Eligible recipients include 501(c)(3) nonprofit institutions, state and local government entities, and tribal organizations. Projects must address determinants of health disparities through intervention studies, implementation research, or etiologic studies in rural communities. Both clinical trials and non-trial research are supported.
Geographic scope is national. Any rural U.S. population can be studied. The NIH expects grantee institutions to have research infrastructure and fiscal accountability systems in place.
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Key dates
- May 27, 2025 Applications open
- Nov 26, 2025 Application deadline
- Apr 1, 2026 Award announced
- Apr 1, 2026 Project start
Program description
The National Institute on Minority Health and Health Disparities (NIMHD) intends to publish a Notice of Funding Opportunity (NOFO) to support intervention and etiologic studies in rural communities to address factors that increase, reduce, or prevent disparities in health outcomes among rural populations. Areas of research interest that may be addressed include but are not limited to:
- Studies that utilize the life course continuum to address health disparities in rural populations considering risk factors that differentially impact health.
- Development, adaptation, and/or implementation of community-engaged interventions that improve quality of life, well-being, and health outcomes in rural populations.
- Adaptation of technologies (e.g., virtual care, remote monitoring) to address access to healthcare resources in rural areas.
- Health service and care models that focus on ways to improve rural health and meet related needs through local community collaborations such as with churches, schools, libraries, and grocery stores.
- Studies that investigate health-related resilience or protective factors as well as strategies to promote health.
- Studies that examine the integration of health care systems and community services (e.g., public health departments, mining facilities, agricultural farms, health systems, school systems, community-based organizations, businesses, etc.) to address rural health disparities.
- Implementation studies to advance the reach, effectiveness, and sustainability of evidence-based interventions in rural communities.
This NOFO will utilize the R01 activity code.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- County Government
- Hospital
- Private University
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Form
- Project Narrative
- Detailed Budget and Budget Justification
- Biosketches (Key Personnel)
- Letters of Support (Community Partners)
- Preliminary Data/Figure
- NIH Format Checklist
Program contact
- 👤 Priscah Mujuru, PhD National Institute on Minority Health and Health Disparities (NIMHD)
- 📧 priscah.mujuru@nih.gov
- 📞 301-402-1366
Funding track record
Recent awards under CFDA 93.307 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$57,145,935
-
$48,558,256
-
$45,796,667
-
$43,100,665
-
$41,194,375
-
$38,870,836
-
$37,991,760
-
$37,142,240
-
$35,966,257
-
$35,161,090
Top States by Funding
- CA 9 awards $245.6M
- NC 4 awards $112.1M
- TX 5 awards $93.2M
- NY 6 awards $91.5M
- GA 3 awards $76.6M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.307). How funding has trended year over year.
| 2018 | $262,996,990 | |
| 2019 | $273,841,218 | |
| 2020 | $334,014,214 | |
| 2021 | $899,466,003 | |
| 2022 | $421,276,230 | |
| 2023 | $540,394,878 | |
| 2024 est. | $489,444,934 | |
| 2025 est. | $489,444,934 |
FAQ
Who is eligible to apply for this R01 grant?
Research institutions including universities, hospitals, and nonprofits may apply. Your organization must have research capacity and fiscal infrastructure. Tribal nations and government agencies also qualify.
When is the deadline?
The Notice of Funding Opportunity has not yet been published. The forecast indicates it will open with a deadline in November 2025.
What types of studies are funded?
Intervention studies, implementation research, technology adaptation, and etiologic studies addressing rural health disparities. Clinical trials are optional but supported.
How competitive is this grant?
R01 grants are highly competitive nationally. Success rates typically range 15-25%. Strong preliminary data and experienced research teams are essential.
What is the typical funding amount?
R01 awards vary. Review recent NIMHD R01 awards in your field for realistic targets. Current NIH award ranges are substantial but vary by discipline.
💡 Tips for applicants
- Start building partnerships with rural community organizations, schools, churches, and health departments now. Community engagement is essential to competitiveness.
- Develop strong preliminary data showing feasibility in your target rural population. NIH reviewers expect evidence before funding research.
- Focus on health disparities drivers, not just rural health generally. NIMHD prioritizes addressing inequities, not universal rural issues.
- Design for sustainability and implementation from the start. Studies showing how interventions can scale and persist score higher.
- Use the R01 format even though the NOFO hasn't launched. Familiarize yourself with NIH R01 requirements and biosketches now to save time later.
⚠️ Common mistakes
Ignoring community partnership and engagement. Reviewers expect genuine collaboration with rural communities, not extractive research. Studies without preliminary data in the target population rarely succeed. Being too broad on rural issues; successful proposals focus sharply on specific health disparities and mechanisms.
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