Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer’s Dementia (R01 Clinical Trial Optional)
Can you apply?
This grant is for research on neuropsychiatric symptoms in Alzheimer's dementia using NIH's R01 mechanism. Eligible applicants include research institutions, universities, medical centers, and nonprofit organizations with 501(c)(3) status or equivalent. The grant supports basic, translational, and clinical research including optional clinical trials. Applicants must have appropriate institutional infrastructure and investigator qualifications to conduct rigorous neuroscience and dementia research.
This grant is for research on neuropsychiatric symptoms in Alzheimer's dementia using NIH's R01 mechanism. Eligible applicants include research institutions, universities, medical centers, and nonprofit organizations with 501(c)(3) status or equivalent. The grant supports basic, translational, and clinical research including optional clinical trials. Applicants must have appropriate institutional infrastructure and investigator qualifications to conduct rigorous neuroscience and dementia research.
Program description
The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer’s disease (AD) or Alzheimer’s disease-related dementias (ADRD). The findings are expected to advance mechanistic understanding of both biobehavioral and neurobiological pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
Details
This grant is for research on neuropsychiatric symptoms in Alzheimer's dementia using NIH's R01 mechanism. Eligible applicants include research institutions, universities, medical centers, and nonprofit organizations with 501(c)(3) status or equivalent. The grant supports basic, translational, and clinical research including optional clinical trials. Applicants must have appropriate institutional infrastructure and investigator qualifications to conduct rigorous neuroscience and dementia research.
How to apply
Application links
Required documents
- SF-424 (R&R) form
- Project Narrative (Specific Aims, Research Strategy, etc.)
- Biographical Sketches (NIH format)
- Budget and Budget Justification
- Institutional Support/Vertebrate Animals/Human Subjects forms (if applicable)
- Letters of Support from collaborators
- Previous Research Support documentation
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.242 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$75,056,208
-
$74,756,329
-
$72,845,834
-
$64,705,159
-
$63,991,707
-
$54,214,022
-
$38,895,082
-
$38,475,557
-
$34,635,977
-
$34,475,710
Top States by Funding
- CA 15 awards $408.1M
- MA 9 awards $230.3M
- NY 6 awards $184.2M
- WA 4 awards $174.9M
- CT 3 awards $138.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.242). How funding has trended year over year.
| 2024 | $1,722,300,004 | |
| 2025 | $1,726,864,191 | |
| 2026 est. | $99,221,272 |
FAQ
Who can apply for this grant?
Research institutions, universities, medical centers, and 501(c)(3) nonprofits are eligible. Your institution must have an active Federal Unique Entity Identifier (SAM registration). Postdoctoral researchers can be PIs on some NIH mechanisms, but typically require mentorship.
What research is supported?
Novel mechanistic research on neuropsychiatric symptoms in Alzheimer's dementia. Clinical trials are optional but allowed. Study populations, animal models, and translational approaches are all eligible.
What is the typical funding range?
R01 grants typically support $100,000–$500,000 per year depending on research scope and complexity. NIH budgets vary by institute and scientific area.
What is the deadline and timeline?
The deadline is September 7, 2026. Plan to submit 6–8 weeks before the deadline. Review timelines typically take 3–6 months after submission.
How competitive is this grant?
R01 grants are highly competitive with success rates typically 20–25%. Strong preliminary data, clear innovation, and experienced teams strengthen competitiveness significantly.
💡 Tips for applicants
- Build preliminary data before applying. NIH reviewers expect strong foundational evidence supporting your research hypothesis.
- Align your specific aims with current understanding of neuropsychiatric mechanisms in Alzheimer's. Show how your work advances the field beyond existing knowledge.
- Plan realistic timelines and budgets. Underestimating costs or timelines raises red flags with reviewers.
- Engage biostatisticians and dementia experts early. Collaborate with established researchers if you're new to this specific research area.
- Write a compelling abstract and significance section. Most reviewers skim these sections first—clarity and impact matter enormously.
⚠️ Common mistakes
Weak preliminary data or unclear mechanistic novelty. Vague hypotheses or aims lacking specificity. Underestimating project complexity, timeline, or budget needs.
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