Mechanisms that Impact Cancer Risk after Bariatric Surgery (R01 Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for research on how bariatric surgery affects cancer risk through mechanistic studies. NIH R01 awards typically support independent researchers with doctoral degrees at academic institutions, government labs, or research-focused nonprofits. Institutions must have 501(c)(3) status or be public entities. Applicants can be at any career stage, though postdocs may face competitiveness. Geographic scope is nationwide; international collaborators are permitted but awardees must be U.S. based.
This program funds basic and clinical research examining biological mechanisms linking bariatric surgery to cancer risk changes. Studies can include human subjects (clinical trial optional), animal models, and mechanistic investigations. Human subjects research requires IRB approval. Budget support typically ranges $250,000–$500,000 for direct costs annually.
Both domestic and foreign institutions may participate as partners. Applicants need institutional support (department chair approval, grants administrator availability). Prior NIH funding is not required but strengthens competitiveness.
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Program description
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Researcher (independent)
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Required documents
- SF-424 (R&R) form
- Project Narrative (Specific Aims, Research Strategy, significance)
- Detailed Budget and Budget Justification
- Biographical Sketches (key personnel, max 5 pages each)
- Facilities and Resources documentation
- IRB approval letter (if human subjects research)
- Letters of Support (collaborating institutions)
- Human Subjects Protection documentation (if applicable)
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.399 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$22,629,848
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$20,187,190
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$19,625,661
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$19,227,026
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$18,138,327
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$17,827,646
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$17,614,587
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$16,535,118
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$16,126,587
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$14,347,054
Top States by Funding
- NY 7 awards $57.6M
- SC 3 awards $46.6M
- DE 3 awards $43.2M
- IL 3 awards $38.4M
- WI 3 awards $37.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
FAQ
Who is eligible to apply for this NIH R01?
Researchers with doctoral degrees (MD, PhD, or equivalent) at research institutions, including universities, nonprofits, and government labs. Postdocs can apply if they meet career stage requirements.
What is the typical funding range?
NIH R01 awards typically range $250,000–$500,000 in direct costs annually, often for 5-year projects.
Can my project include human subjects?
Yes. Clinical trials are optional here. If you include human subjects, IRB approval is required before funding begins.
What makes applications competitive?
Strong preliminary data, clear mechanistic hypotheses, experienced research team, and feasible methodology. Projects addressing cancer disparities gain additional priority.
When is the application due?
The deadline is January 7, 2028. Submit through Grants.gov at least 24 hours before the deadline.
💡 Tips for applicants
- Start with strong preliminary data showing mechanisms linking bariatric surgery to cancer risk changes. Reviewers expect proof-of-concept evidence.
- Use clear, testable hypotheses grounded in current cancer biology literature. Avoid vague mechanistic proposals.
- If your project includes clinical components, clarify how bariatric surgery patients will be recruited and retained. Follow-up compliance is crucial.
- Address both obesity-protective and obesity-risk pathways. Reviewers want nuanced mechanistic understanding, not just "weight loss helps."
- Allow 2–3 months before the deadline for institutional review, grant administrator sign-offs, and Grants.gov submission troubleshooting.
⚠️ Common mistakes
Proposing descriptive studies without clear mechanistic hypotheses. NIH R01s require testable, specific aims with biological plausibility.
Underestimating recruitment timelines for human subjects. Bariatric surgery patient cohorts require careful planning and realistic enrollment schedules.
Ignoring established cancer prevention literature. Reviewers expect integration with current knowledge on obesity, metabolism, and carcinogenesis.
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