Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for research organizations and institutions seeking to fund NIH research projects on cancer screening and preventive services in underserved populations. Eligible applicants include academic institutions, research hospitals, nonprofit organizations, and federally qualified health centers with research capacity. The project must include a clinical trial component testing interventions to reduce cancer screening disparities. Priority goes to proposals addressing health equity and serving populations experiencing documented health disparities.
Funding supports domestic research locations. International collaborations may be included but projects must have significant U.S.-based components. Research institutions must have the infrastructure to conduct clinical trials and manage federal grants. All research must comply with NIH regulations for human subjects protection and clinical trial oversight.
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Program description
The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICs) are issuing this R01 to solicit applications to address barriers and facilitators that impede use or uptake of cancer screening and preventive services in populations that experience health disparities.
Interventions should include screening, preventive services, or other healthcare processes, including timely follow-up of abnormal findings, and referral to accessible care. Projects are encouraged to leverage collaborations with community partners and service providers. Interventions should address barriers and facilitators at two or more of the following levels: patient, clinician, healthcare setting, and neighborhood/community. Specific research interests of participating NIH ICs are detailed within.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Required documents
- SF-424 (R&R)
- Project Narrative (Research Plan)
- Detailed Budget and Budget Justification
- Biosketch for all key personnel
- Literature Cited
- IRB approval letter or evidence of IRB review
- Clinical Trial protocol or detailed trial methodology
- Letters of support from partner institutions/sites
- DUNS number and institutional registration documentation
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.399 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$22,629,848
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$20,187,190
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$19,625,661
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$19,227,026
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$18,138,327
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$17,827,646
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$17,614,587
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$16,535,118
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$16,126,587
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$14,347,054
Top States by Funding
- NY 7 awards $57.6M
- SC 3 awards $46.6M
- DE 3 awards $43.2M
- IL 3 awards $38.4M
- WI 3 awards $37.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
FAQ
Can nonprofits without research institutions apply for this R01?
Nonprofits must have research capacity and IRB approval capability. Most applicants are academic medical centers, research hospitals, or established research organizations with clinical trial experience.
Is a clinical trial required?
Yes. All applications must include a clinical trial component testing cancer screening interventions. This is a mandatory requirement for this funding opportunity.
What populations are prioritized?
Priority goes to research targeting health disparities in underserved populations. This includes low-income communities, racial/ethnic minorities, rural populations, and other groups with documented screening gaps.
How competitive is this grant?
R01 grants are highly competitive. NIH research grants typically receive thousands of applications with funding rates around 20-25%. Strong preliminary data and feasibility are essential.
What is the typical funding range?
R01 grants vary widely by field and scope. Cancer research typically ranges from $250K to $500K+ annually. Budget must be justified by the research plan.
💡 Tips for applicants
- Demonstrate health disparities in your target population using epidemiologic data and clear statistics.
- Show strong preliminary data from pilot work or previous studies testing your screening intervention.
- Design a rigorous clinical trial with clear endpoints and feasible recruitment/retention plans.
- Build partnerships with clinical sites serving your priority population to ensure authentic community engagement.
- Address sustainability: explain how the screening program could continue after grant funding ends.
⚠️ Common mistakes
Applications lack rigorous preliminary data or clear clinical trial design. Applicants underestimate the time/cost needed for clinical trial recruitment in underserved populations. Proposals focus on screening without adequate attention to health equity or disparities reduction mechanisms.
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