DoW Tuberous Sclerosis Complex, Clinical Translational Research Award
🏛 Defense Health Agency Contracting Activity - DHACA (DOD-AMRAA)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for researchers pursuing clinical translational studies on Tuberous Sclerosis Complex (TSC). Eligible applicants typically include academic institutions, research hospitals, and nonprofit research organizations with established research capabilities. Applicants must have institutional capacity to conduct clinical research and regulatory approval processes. The program supports early-to-mid-stage research moving from bench discoveries toward patient applications.
Geographic scope is nationwide. Any U.S.-based institution may apply if it meets research infrastructure requirements. Foreign institutions may be eligible under specific partnership arrangements.
Funded activities include clinical translation research, pilot studies, and preliminary investigations. Applications should demonstrate clear pathways from basic findings to clinical testing or therapeutic development for TSC patients.
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Program description
Summary: The fiscal year 2026 (FY26) Tuberous Sclerosis Complex Research Program (TSCRP) Clinical Translational Research Award (CTRA) supports studies that will move promising, well-founded preclinical and/or clinical research findings closer to clinical application, including diagnosis, prognosis or treatment of tuberous sclerosis complex (TSC).
Distinctive Features: This funding mechanism allows for multiple Principal Investigators (PIs). Only the initiating PI will submit a pre-application, but all PIs will need to submit full applications. The partnering PI(s) application is an abbreviated package specific to their distinct portion of the research project. Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Federal Application for Grant or Cooperative Agreement)
- Detailed Project Narrative with research plan and clinical translation strategy
- Budget and Budget Justification
- Biographical Sketches of Key Personnel (NIH format)
- Letters of Institutional Support and Resource Commitment
- IRB Approval or Approval Plans and Regulatory Documentation
- Preliminary Data and Feasibility Documentation
- Letters of Support from Clinical Collaborators
Program contact
- 👤 JoAnn Martin Grantor
- 📧 help@eBRAP.org
- 📞 301-619-2594
Funding track record
Recent awards under CFDA 12.420 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$2,265,729,366
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$800,631,761
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$74,531,880
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$67,205,571
-
$55,443,120
-
$34,191,124
-
$24,907,742
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$21,394,379
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$19,100,256
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$19,002,641
Top States by Funding
- MD 10 awards $3,150.1M
- NC 11 awards $132.3M
- CA 12 awards $107.3M
- FL 8 awards $99.8M
- TX 8 awards $76.5M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 12.420). How funding has trended year over year.
| 2024 | $1,483,968,520 | |
| 2025 | $1,201,153,417 |
FAQ
Who can apply for this award?
Academic medical centers, universities, research hospitals, and nonprofit research organizations with clinical research infrastructure. Your institution must have IRB and regulatory approval capacity.
What is the typical funding range?
Clinical translational awards typically range from $200,000 to $500,000 annually, though exact amounts vary by competition year. Check the funding opportunity announcement for specific details.
What types of research are supported?
Early clinical translation studies, pilot clinical investigations, and translational research moving from laboratory findings toward patient applications. Applied clinical studies are prioritized over basic research.
What is the application deadline?
The fixed deadline is August 6, 2026. Applications must be submitted by 11:59 PM Eastern Time on that date. No extensions are typically granted for fixed deadlines.
How competitive is this grant?
DoD research funding is highly competitive. Success rates typically range 15-25% depending on the specific program. Strong preliminary data and clear clinical relevance are essential.
💡 Tips for applicants
- Emphasize clinical translation and patient impact. Show how your work bridges laboratory findings and patient care for TSC.
- Develop strong preliminary data in your target population. DoD reviewers prioritize feasibility and proof-of-concept evidence.
- Include letters of support from clinical collaborators and institutional research administration. Demonstrate institutional commitment to the project.
- Clearly define measurable milestones and go/no-go decision points. DoD values transparent project management and accountability.
- Address regulatory and ethical considerations upfront. Include IRB protocols, informed consent plans, and participant safety protocols in detail.
⚠️ Common mistakes
Applications often lack sufficient preliminary clinical data or feasibility demonstration. Reviewers want to see proof-of-concept, not just theoretical potential. Weak institutional support letters or unclear regulatory pathways cause rejections. Applicants sometimes oversell basic research components instead of emphasizing clinical translation and patient benefit.
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