Cancer Advancement through Partnerships in Research and Infrastructure (CAPRI) (U54 Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 19, 2026
Can you apply?
This grant is for research institutions and cancer centers pursuing comprehensive cancer research and health equity improvements. Eligible applicants include research universities, academic medical centers, cancer research organizations, and established cancer centers. The program supports research that addresses cancer prevention, detection, treatment, and survivorship across diverse populations. Geographic scope is nationwide. Activities include clinical and translational research, community-engaged studies, and efforts to reduce cancer disparities.
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Key dates
- Aug 31, 2026 Applications open
- Sep 1, 2026 Award announced
- Sep 1, 2026 Project start
- Jan 25, 2027 Application deadline in 97 days
Program description
This funding opportunity seeks to support the Comprehensive Partnerships to Advance Cancer Health (CPACH) Program. The CPACH Program develops and maintains comprehensive, long-term, mutually beneficial partnerships between Resource Limited Institutions (RLIs) and NCI-designated Cancer Centers (CCs). The program aims to achieve a stronger national cancer program and addresses challenges in cancer research, including a focus on advancing research on health drivers that contribute to differences in cancer outcomes across all populations, as well as cancer outreach and engagement.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Federal Application for Research
- Project Narrative and Research Plan
- Budget and Budget Justification
- Biographical Sketches (key personnel)
- Institutional Support Letters
- Evidence of IRB approval or exemption (if human subjects involved)
- Letters of Commitment from partner organizations
Program contact
- 👤 Sandra San Miguel-Majors, DrPH, MS
- 📧 ncicpachU54@mail.nih.gov
- 📞 2402765977
Funding track record
Recent awards under CFDA 93.399 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$31,699,712
-
$23,221,095
-
$22,629,848
-
$20,624,330
-
$20,449,106
-
$20,018,954
-
$19,957,085
-
$17,864,446
-
$16,730,455
-
$16,126,587
Top States by Funding
- NY 7 awards $64.5M
- SC 3 awards $52.1M
- IL 4 awards $48.9M
- WI 4 awards $48.2M
- PA 4 awards $41.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.398). How funding has trended year over year.
| 2024 | $228,173,992 | |
| 2025 | $213,201,522 | |
| 2026 est. | $135,455,000 |
FAQ
Who can apply for CPACH grants?
Research universities, academic medical centers, cancer centers, and nonprofit research institutions with 501(c)(3) status are typically eligible. Your institution must have demonstrated cancer research capacity.
Is this a clinical trial grant?
Yes, clinical trials are optional. You can pursue basic research, translational research, or clinical research depending on your organization's focus.
What research areas does CPACH support?
The program funds cancer prevention, detection, treatment, survivorship, and health equity research. Community engagement and reducing cancer disparities are priority areas.
How competitive is this grant?
NIH grants are highly competitive. Expect rigorous peer review of scientific merit, research team qualifications, and institutional capacity.
What is the typical funding amount?
NIH U54 grants typically range from $500K to $2M+ annually, depending on research scope and institutional resources. Check the specific funding opportunity announcement for exact amounts.
💡 Tips for applicants
- Build a strong multi-institutional team. Partnerships with community organizations and healthcare systems strengthen applications.
- Focus on health equity and reducing cancer disparities in underserved populations. This aligns with current NIH priorities.
- Use preliminary data to demonstrate feasibility. Show that your team can execute the proposed research successfully.
- Plan detailed evaluation metrics. NIH reviewers expect clear, measurable outcomes for all research activities.
- Start early on your institutional support letters. Your university/research institution must demonstrate commitment to the project.
⚠️ Common mistakes
Weak community engagement plans or lack of diversity in research populations. Proposing unrealistic timelines or budgets without sufficient preliminary data. Failing to address how research findings will reduce cancer disparities.
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