Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)
Can you apply?
This grant is for institutions seeking comprehensive support for NCI-designated Cancer Centers. Eligible applicants include academic medical centers, research hospitals, and research-intensive institutions with active cancer research programs. Institutions must be designated by NCI or applying for renewal of existing designation. The grant supports cancer research infrastructure, shared resources, and administrative needs. Geographic scope covers the entire United States, including U.S. territories.
Key dates
- Mar 10, 2026 Applications open
- Jan 25, 2027 Application deadline in 237 days
- Dec 1, 2027 Award announced
- Dec 1, 2027 Project start
This grant is for institutions seeking comprehensive support for NCI-designated Cancer Centers. Eligible applicants include academic medical centers, research hospitals, and research-intensive institutions with active cancer research programs. Institutions must be designated by NCI or applying for renewal of existing designation. The grant supports cancer research infrastructure, shared resources, and administrative needs. Geographic scope covers the entire United States, including U.S. territories.
Program description
This Notice of Funding Opportunity (NOFO) invites applications for P30 Cancer Center Support Grants (CCSGs) to support NCI-Designated Cancer Centers. CCSGs support three types of Cancer Centers: 1) Comprehensive Cancer Centers, which demonstrate reasonable depth and breadth of research activities in each of three major areas: basic laboratory; clinical; and prevention, control and population-based research, and which have substantial transdisciplinary research that bridges these scientific areas; and 2) Clinical Cancer Centers, which are primarily focused on basic laboratory; clinical; and prevention, cancer control, and population-based research; or some combination of these areas, and 3) Basic Cancer Centers, which focus on basic laboratory research. The purpose of all types of NCI-Designated Cancer Centers is to capitalize on all institutional cancer research capabilities, integrating meritorious research into a single transdisciplinary research enterprise across all institutional boundaries. Cancer Centers supported through this NOFO are expected to serve as major sources of discovery of the nature of cancer and of development of more effective approaches to prevention, diagnosis, and therapy; to contribute significantly to the development of Shared Resources that support research; to collaborate and coordinate their research efforts with other NCI-funded programs and investigators; and to disseminate research findings for the benefit of the community.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Details
This grant is for institutions seeking comprehensive support for NCI-designated Cancer Centers. Eligible applicants include academic medical centers, research hospitals, and research-intensive institutions with active cancer research programs. Institutions must be designated by NCI or applying for renewal of existing designation. The grant supports cancer research infrastructure, shared resources, and administrative needs. Geographic scope covers the entire United States, including U.S. territories.
How to apply
Application links
Key dates & requirements
Required documents
- Institutional Background and Environment
- Cancer Center Organizational Structure
- Shared Resources and Core Facility Descriptions
- Research Portfolio Summary
- Resource Management and Budget Plans
- Cancer Center Director's Statement
- Institutional Commitment Letters
- SF-424 Federal Application Forms (if required by program announcement)
Program contact
- 👤 Office of Cancer Centers, National Cancer Institute (NCI)
- 📧 ncicenters-r@mail.nih.gov
- 📞 240-276-5600
Funding track record
Recent awards under CFDA 93.397 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$263,969,536
-
$235,803,541
-
$221,888,292
-
$203,145,019
-
$163,189,642
-
$140,362,092
-
$127,756,828
-
$127,128,807
-
$123,361,385
-
$122,762,660
Top States by Funding
- CA 13 awards $897.9M
- NY 6 awards $623.7M
- MA 5 awards $446.7M
- PA 6 awards $442.8M
- TX 7 awards $430.6M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.397). How funding has trended year over year.
| 2024 | $608,105,052 | |
| 2025 | $607,075,632 | |
| 2026 est. | $338,673,000 |
FAQ
Who can apply for a CCSG?
Academic medical centers and research-intensive institutions with robust cancer research programs can apply. Your institution must have NCI-designated center status or be eligible to apply for it.
What activities does this grant fund?
Funding supports research infrastructure, core facilities, shared research resources, and administrative costs. It does not fund individual investigator salaries or direct research project costs.
How is this grant different from regular NIH grants?
CCSGs provide institutional support for cancer center operations and resources. They fund shared facilities and cores rather than individual research projects.
What is the timeline for the application?
Application deadlines are set by NIH and typically follow specific cycles. Check the NIH CCSG program announcement for exact deadline dates.
How competitive is this grant?
These grants are highly competitive and based on institutional capacity, research portfolio strength, and resource management plans. Strong past performance is essential.
💡 Tips for applicants
- Demonstrate strong institutional commitment through resource allocation and infrastructure investment. Include letters of institutional support from leadership.
- Emphasize the breadth and quality of your cancer research portfolio across multiple research areas. Show interdisciplinary collaboration among cancer researchers.
- Develop detailed, realistic plans for shared core facilities and resources. Explain how cores will serve the broader cancer research community.
- Use preliminary data and outcomes from your existing programs to document impact. Show how resources have advanced cancer research outcomes.
- Start the application 6+ months before the deadline. Coordinate closely with your NIH program officer throughout the process.
⚠️ Common mistakes
Applications underestimate core facility utilization and fail to justify funding levels against actual research capacity. Institutions provide insufficient evidence of NCI-designated cancer center status or eligibility.
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