Alcohol Health Services Research (R01 Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for researchers and institutions seeking to conduct clinical research on alcohol health services, prevention, and treatment. Eligible applicants typically include academic medical centers, research institutions, nonprofit organizations with research capacity, and some government agencies. The grant supports both basic and applied research investigating alcohol-related health issues, treatment effectiveness, service delivery models, and health disparities. Projects may include clinical trials (optional), observational studies, implementation research, and services research. Both domestic and international sites may be eligible depending on specific program requirements. Applicants must have institutional support, relevant research infrastructure, and qualified personnel to conduct the proposed research.
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Program description
The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Community Health Center
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Required documents
- SF-424 (R&R) application form and SF-424 (R&R) cover letter
- Project narrative (specific aims, significance, innovation, approach—typically 15 pages)
- Bibliography and references
- Budget narrative and detailed budget (SF-424 R&R Budget form)
- Budget justification
- NIH biographical sketch for PD/PI and key personnel (5 pages each)
- Current and pending support documentation
- Institutional support letter(s) and facility descriptions
- Vertebrate animals section (if applicable)
- Human subjects research documentation (IRB approval status, informed consent forms if applicable)
- Letters of support from collaborating institutions
- Data management and sharing plan
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.273 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$125,900,663
-
$34,675,742
-
$34,469,501
-
$33,261,336
-
$32,897,567
-
$31,652,514
-
$30,394,602
-
$29,223,384
-
$29,195,978
-
$29,168,993
Top States by Funding
- CA 15 awards $242.3M
- NY 3 awards $162.6M
- OR 7 awards $96.3M
- NC 4 awards $67.1M
- IN 3 awards $57.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.273). How funding has trended year over year.
| 2024 | $430,377,419 | |
| 2025 | $429,906,735 | |
| 2026 est. | $12,401,560 |
FAQ
Who is eligible to apply for this grant?
Researchers at academic institutions, medical centers, nonprofits with research capacity, and some government agencies can apply. Principal investigators must have appropriate doctoral degrees (PhD, MD, DO, DVM, etc.) and demonstrated research experience.
What is the application deadline?
The fixed deadline is September 7, 2026. Applications must be submitted through NIH's electronic system before the deadline. Applications submitted after the deadline will be returned without review.
What types of research activities are supported?
This grant supports clinical research on alcohol-related health services, including clinical trials, observational studies, implementation science, health services research, and studies examining treatment efficacy, accessibility, and health disparities.
How competitive is this grant?
NIH R01 grants are highly competitive. Success rates typically range from 15-25%. Applications must demonstrate scientific significance, methodological rigor, and a strong likelihood of contributing important new knowledge to the field.
What is the typical funding range?
R01 grants typically provide $100,000-$500,000+ in annual direct costs, with project periods of three to five years. Actual amounts vary based on scientific scope and reviewer assessment of resource needs.
💡 Tips for applicants
- Ensure your research question addresses a significant gap in alcohol health services knowledge and has clear public health relevance. Reviewers look for compelling preliminary data and evidence of feasibility.
- Build a multidisciplinary team with complementary expertise in clinical research, alcohol-related health, biostatistics, and relevant health service domains. Strong institutional collaboration strengthens competitiveness.
- Develop a detailed, realistic budget and timeline. Clearly justify all proposed resources and demonstrate that the budget aligns with the scope of work and timeline.
- If including a clinical trial component, pre-plan regulatory requirements (IRB approval, IND applications if applicable, safety monitoring plans). Describe your recruitment and retention strategies with realistic timelines.
- Follow NIH formatting requirements precisely, use their SPA (Specific Program Announcement) guidance if available, and allocate sufficient time for internal institutional review before submission. Consider seeking feedback from NIH Program Officers during proposal development.
⚠️ Common mistakes
Applications are often rejected for lacking sufficient preliminary data to demonstrate feasibility, having overly ambitious scopes that don't fit the timeline and budget, or failing to clearly articulate how the research addresses health disparities or advances evidence-based alcohol treatment and prevention. Weak study designs, inadequate data management plans, and unclear connections between research aims and public health impact are also common reasons for rejection.
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