Biomedical Research – Research Projects (RP)

CFDA 93.GM1 Active Grant Cooperative Agreement

Program Funding

Annual program obligations reported to SAM.gov.

Latest annual funding (estimated)
$2.15B FY2026
$2.05B
FY24
$2.15B
FY25
$2.15B
FY26*
* estimated

Program Objective

The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS also supports research in specific clinical areas that affect multiple organ systems: anesthesiology and peri-operative pain; clinical pharmacology common to multiple drugs and treatments; and injury, critical illness, sepsis, and wound healing. NIGMS-funded scientists investigate how living systems work at a range of levels—from molecules and cells to tissues and organs—in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in supporting the training of future scientists and developing research capacity throughout the country.

Eligibility

Eligible Applicants

  • State
  • Local
  • Nonprofit Organization
  • Federally Recognized Tribal Government

Description of who is eligible to apply will be published in the NOFO.

How to Apply

Award Procedure

In calculating budgets for grants, NIGMS staff considers each budget carefully and takes into account the science being conducted, the other support for the PI’s lab, the Institute’s budget, and other factors. PIs should not assume that they will be awarded the amount recommended by the study section. To fund as broad a portfolio of meritorious investigators as soon as possible and to improve overall returns on investments, NIGMS pays close attention to budget levels and gives large budget increases only in highly compelling cases. Applicants are encouraged to contact NIGMS program staff with questions.

Decision Timeline

  • Approval: > 180 Days
Program details & compliance

Description

The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.

Mission Categories

Primary: Research and Development

Other categories:
Prevention and Control (includes Suicide Prevention)

Required Documentation

Each applicant for research projects must present a research plan and furnish evidence that scientific competence, facilities, equipment, and supplies are appropriate to carry out the plan.

Reporting & Compliance

Audit Required
Yes — Determined at Time of Award
Records Retention
3 years

Applicable 2 CFR 200 Subparts

  • Subpart B — General Provisions
  • Subpart C — Pre-Federal Award Requirements
  • Subpart D — Post-Federal Award Requirements
  • Subpart E — Cost Principles
  • Subpart F — Audit Requirements

Contacts

National Institute of General Medical Sciences
(301) 496-7301
45 Center Drive MSC6200, Bethesda, MD 20892
Data from SAM.gov Federal Assistance Listings. Source published: 2026-01-28. Spec v2.0. Last synced: 2026-05-29 05:40:15.