Maternal and Pediatric Precision in Therapeutics (MPRINT) Knowledge and Research Coordination Center
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions establishing a Knowledge and Research Coordination Center focused on maternal and pediatric drug development. Eligible applicants typically include academic medical centers, research universities, and organizations with demonstrated capacity in clinical research, data science, and regulatory science. The center will serve as a hub coordinating multi-institutional collaborations in therapeutics research, drug safety, and clinical trials. Applicants must show expertise in maternal health, pediatric medicine, pharmacology, and real-world evidence generation.
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Key dates
- Sep 15, 2025 Applications open
- Mar 2, 2026 Application deadline
- Dec 1, 2026 Award announced
- Dec 1, 2026 Project start
Program description
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to establish a Knowledge and Research Coordination Center as part of the NICHD’s Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub. The MPRINT KRCC will accelerate safe, effective drug development and regulatory science through expanding the available knowledge, tools, and expertise in maternal and pediatric therapeutics by: (1) Developing an easily queryable curated and interoperable pharmacology knowledgebase; (2) Leveraging real-world clinical data and insights, particularly through mother-baby linkages; (3) Supporting and leveraging efficient and innovative clinical trials in pediatrics, obstetrics, and lactation; (4) Uniting multidisciplinary expertise and training the future workforce. The Center will collaborate with MPRINT’s Maternal Medication and Human Milk Research Center (M2HMRC) to conduct cutting-edge clinical, translational, and data science research. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will support cooperative agreements involving large-scale research activities with complex structures.
Grant authorities that allow the Eunice Kennedy Shriver National Institute of Child Health and Human Development to forecast this opportunity are as follows: Public Health Service Act, Section 301, 448 and 487, as amended, Public Laws 78-410 and 99-158, as amended, 42 U.S.C. 241; 42 U.S.C. 285g; 42 U.S.C. 288; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564, Public Law 118-47.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Federal Application for Federal Assistance)
- SF-424 R&R (Research & Related)
- Project Narrative/Research Plan
- Facilities & Administrative (F&A) Cost Rate Agreement
- Letters of Support from Collaborating Institutions
- Budget and Budget Justification
- Biographical Sketches of Key Personnel
Program contact
- 👤 Lesly-Anne Samedy-Bates, Pharm.D., Ph.D., M.S.
- 📧 lesly-anne.samedy-bates@nih.gov
- 📞 301-219-7492
Funding track record
Recent awards under CFDA 93.865 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$1,073,967,938
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$719,372,575
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$276,059,721
-
$155,556,396
-
$155,482,198
-
$103,665,364
-
$74,151,078
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$72,701,366
-
$52,238,426
-
$47,450,377
Top States by Funding
- WA 1 awards $1,074.0M
- NC 7 awards $925.9M
- MD 4 awards $501.6M
- MA 3 awards $190.0M
- PA 3 awards $145.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.865). How funding has trended year over year.
| 2024 | $1,282,226,682 | |
| 2025 | $1,333,391,690 | |
| 2026 est. | $184,920,723 |
FAQ
Who can apply for this grant?
Large research institutions with significant infrastructure for clinical research, data science, and multidisciplinary collaboration. Organizations must demonstrate experience in maternal and pediatric therapeutics research.
What is the deadline?
The Notice of Funding Opportunity is expected March 2, 2026. Applications are not being solicited yet; this is advance notice for collaboration planning.
What will the center do?
Develop drug knowledge databases, conduct maternal and pediatric clinical research, support innovative trials, and train the next generation of researchers in therapeutics.
Is cost-sharing required?
No, this is a federal cooperative agreement with no required cost-sharing from applicants.
How competitive is this opportunity?
Very competitive. NICHD cooperative agreements typically fund large-scale research centers with complex infrastructure and multi-institutional partnerships. Strong preliminary data and established collaborations are essential.
💡 Tips for applicants
- Start building collaborations now. The NOFO advises applicants to develop meaningful partnerships before the deadline.
- Emphasize your institution's clinical trial infrastructure and real-world data capabilities. These are core to the center's mission.
- Highlight multidisciplinary expertise spanning pediatrics, obstetrics, pharmacology, data science, and regulatory science.
- Plan for a robust data management and bioinformatics component. The knowledge base development is a key deliverable.
- Document your experience with mother-baby linkage studies and maternal medication research if applicable.
⚠️ Common mistakes
Underestimating the complexity of managing a multi-institutional cooperative agreement. Applications without demonstrated clinical trial infrastructure or pediatric research capacity are unlikely to be competitive. Failing to clearly articulate how the proposed center advances both maternal and pediatric drug development simultaneously.
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