National Center for Advancing Translational Sciences – Small Business

NCATS - SBIR/STTR
CFDA 93.TR5 Active Grant Cooperative Agreement

Program Funding

Annual program obligations reported to SAM.gov.

Latest annual funding (estimated)
$22.6M FY2026
$22.6M
FY26*
* estimated

Program Objective

The National Center for Advancing Translational Sciences' (NCATS') mission is to turn research observations into health solutions through translational science. We work to develop or enhance the development, testing, and implementation of diagnostics and therapeutics for a wide range of diseases and conditions. Key approaches include understanding what’s similar across diseases to spur multiple treatments at a time, developing models that better predict a person’s reaction to treatment, enhancing clinical trials so results more accurately reflect the patient population, and leveraging real-world data and data science approaches to address public health needs. Facilitating these approaches are our robust partnerships with other government agencies, including other NIH institutes, centers, and offices; industry; academia; nonprofit organizations; and patients, patient advocates, and other communities. NCATS' vision is to bring more treatments for all people more quickly.

Eligibility

Eligible Applicants

  • Other

How to Apply

Award Procedure

The initial review of applications from eligible institutions is conducted by committees comprised of authorities in various fields of biomedical research and science education, as appropriate. Each application is given a peer evaluation for merit. Recommendations for award are forwarded to the NCATS Advisory Council for the second level of review and recommendation for award.

Decision Timeline

  • Approval: > 180 Days
  • Renewal interval: > 180 Days
  • Appeal: From 15 to 30 days
Program details & compliance

Description

The National Center for Advancing Translational Sciences (NCATS) Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs help small businesses develop and commercialize new translational technologies.

Mission Categories

Primary: Research and Development

Other categories:
General Health and Medical

Use of Funds

Allowed Uses

NCATS is all about getting more treatments to all patients more quickly. A novel drug, device or intervention can take 14 years and $2 billion to develop, with a failure rate exceeding 95%. NCATS is directly addressing this problem by discovering new technologies and other approaches that could greatly accelerate the process of developing and deploying solutions that can be used by all translational researchers. Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs utilize the grant and cooperative agreement mechanisms to help eligible US based small businesses develop new translational technologies that can eventually be commercialized to provide health solutions.

Required Documentation

The required credentials of the applicant are described in the relevant Notice of Funding Opportunity.

Reporting & Compliance

Audit Required
Yes — Annual
Records Retention
3 years

Applicable 2 CFR 200 Subparts

  • Subpart B — General Provisions
  • Subpart C — Pre-Federal Award Requirements
  • Subpart D — Post-Federal Award Requirements
  • Subpart E — Cost Principles
  • Subpart F — Audit Requirements

Contacts

NCATSExtramuralInfo
301-594-8966
9609 Medical Center Drive, Rockville, MD 20850
Data from SAM.gov Federal Assistance Listings. Source published: 2026-02-02. Spec v2.0. Last synced: 2026-05-29 05:38:31.