Pilot Testing, Implementation, and Evaluation of the Cervical, Breast and Colorectal Cancer Clinical Decision Support Tools
🏛 Centers for Disease Control and Prevention - ERA (HHS-CDC-HHSCDCERA)
✓ Free, no account · Source: Grants.gov · Last verified Jul 27, 2026
Can you apply?
This grant is for large health systems implementing evidence-based cancer screening tools. Applicants must be capable of system-wide implementation of clinical decision support tools for cervical, breast, or colorectal cancer within electronic health record systems.
Component A focuses on cervical cancer CDS implementation and evaluation. Component B targets pilot testing of breast and colorectal cancer CDS tools. Both require rigorous assessment of implementation processes and clinical outcomes.
Health systems must demonstrate capacity to integrate tools into existing EHR infrastructure. Organizations should have established clinical workflows and patient populations suitable for testing and evaluation.
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Key dates
- Jul 24, 2026 Applications open
- Mar 23, 2027 Application deadline in 237 days
- Aug 30, 2027 Award announced
- Sep 30, 2027 Project start
Program description
The Centers for Disease Control and Prevention’s (CDC) National Center for Chronic Disease Prevention and Health Promotion is advancing the development of clinical decision support (CDS) tools designed to facilitate evidence-based cancer screening and management at the point of care. These CDS tools integrate up-to-date, computable guidelines into electronic health records systems to support clinicians in real-time clinical decision-making. The CDC has previously developed computer algorithms for cervical, breast, and colorectal cancers.
This NOFO has two components:
- Component A. Cervical Cancer Clinical Decision Support (CDS) tool: This component focuses on the system-wide implementation and evaluation of a publicly available cervical cancer CDS tool within a large health system. The primary objective is to enhance guideline-concordant screening and ensure timely follow-up and management after abnormal results. Applicants are expected to rigorously assess both the implementation processes and the efficacy of the tool in improving cervical cancer screening and management.
- Component B. Breast and Colorectal Cancer CDS tools: This component aims to pilot test publicly available, interoperable CDS tools for breast and colorectal cancer screening. The scope includes technical integration of these tools into real-world electronic health record (EHR) systems within a large health system, comprehensive documentation of the implementation process, and empirical evaluation to assess the accuracy and impact of the tools.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 Federal Grant Application Form
- Project Narrative (implementation and evaluation plan)
- Budget and Budget Justification
- Organizational capacity and EHR infrastructure documentation
- Evidence of clinical team expertise
- Evaluation plan with specific metrics
- Letters of commitment from health system leadership
Program contact
- 👤 Celeste Sanders, PhD
- 📧 researchnofo@cdc.gov
- 📞 (770 )488-2536
Funding track record
Recent awards under CFDA 93.945 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$175,852,665
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$73,430,293
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$64,459,482
-
$43,747,919
-
$38,976,182
-
$28,459,850
-
$24,386,392
-
$21,375,151
-
$19,856,088
-
$19,405,911
Top States by Funding
- GA 8 awards $290.9M
- IL 5 awards $124.2M
- CA 8 awards $105.1M
- MD 3 awards $94.7M
- HI 3 awards $62.3M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.945). How funding has trended year over year.
| 2024 | $27,881,234 | |
| 2025 | $26,755,193 | |
| 2026 est. | $26,755,193 |
FAQ
Who is eligible to apply for this grant?
Large health systems capable of system-wide EHR integration and clinical evaluation. Organizations must have established infrastructure for implementing clinical decision support tools.
What is the deadline for this grant?
The fixed deadline is March 23, 2027. No rolling applications are accepted.
What activities are supported under this grant?
Implementation and evaluation of cervical cancer CDS (Component A), or pilot testing of breast and colorectal cancer CDS (Component B). Both require technical integration, documentation, and rigorous outcome evaluation.
How competitive is this funding?
The $7.25M pool suggests moderate to strong competition. Applicants with existing EHR infrastructure and research capacity will be more competitive.
What is the typical award amount?
Award ranges are not specified in this NOFO. Contact the CDC for guidance on expected funding levels per award.
💡 Tips for applicants
- Demonstrate existing EHR infrastructure and technical capacity for integration before applying. Strong technical readiness increases competitiveness.
- Emphasize your organization's ability to reach diverse patient populations for equitable cancer screening outcomes. Equity focus is increasingly important in CDC cancer grants.
- Document your clinical team's expertise in cancer screening guidelines and workflows. Evidence of guideline knowledge strengthens proposals.
- Plan rigorous evaluation methods upfront using established metrics. CDC values well-designed, methodologically sound evaluation plans.
- Build partnerships with your EHR vendor early to ensure feasibility of tool integration. Technical feasibility is critical to success.
⚠️ Common mistakes
Underestimating technical complexity of EHR integration. Applicants often overlook vendor coordination requirements and system compatibility issues. Lack of rigorous evaluation design. Proposals without detailed metrics and evaluation methodology rarely succeed. Insufficient organizational capacity documentation. CDC requires evidence of implementation infrastructure and clinical expertise.
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