Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 19, 2026
Can you apply?
This grant is for research organizations, medical centers, and academic institutions conducting comparative effectiveness trials to test post-acute interventions and services aimed at improving long-term patient outcomes. Applicants must conduct rigorous clinical trials with robust designs; NIH R01 grants prioritize independent research projects led by researchers with relevant expertise. The program supports research across diverse post-acute settings including skilled nursing facilities, inpatient rehabilitation facilities, long-term care hospitals, and home-based care environments. Eligible applicants are typically established researchers at NIH-approved institutions, though early-stage investigators are also encouraged. Geographic scope is U.S.-based research institutions and organizations. Funded activities include trial design, patient recruitment, intervention implementation, data collection, outcome assessment, and dissemination of findings to improve post-acute care quality.
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Program description
NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults. This Notice of Funding Opportunity (NOFO) encourages clinical trials to establish the effectiveness and test hypotheses regarding moderators, mediators, and mechanisms of action of post-acute phase therapeutic and services interventions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden for promoting optimal longer-term outcomes.
This NOFO is intended to support effectiveness trials testing post-acute phase interventions that are statistically powered to provide a definitive answer regarding the study intervention’s effectiveness. Support for pilot effectiveness trials to evaluate the initial feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches is provided via a companion R34 (Currently TEMP-24814)
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Community Health Center
- County Government
- Hospital
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Required documents
- NIH application form (SF-424 R&R)
- Project narrative (research plan, typically 15 pages)
- Detailed budget and budget justification
- Biosketches of key personnel (PI and co-investigators)
- Letters of institutional support/commitment from collaborating sites
- Preliminary data or feasibility studies
- Statistical analysis plan and power calculations
- Data management and security plan
- Letters of support from post-acute care partner organizations
- Research team organizational chart
- References and literature citations
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.242 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$92,363,814
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$91,890,365
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$67,491,373
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$64,705,159
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$63,991,707
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$48,653,752
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$40,395,082
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$38,475,557
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$36,135,833
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$35,940,675
Top States by Funding
- CA 15 awards $433.4M
- MA 10 awards $257.3M
- WA 4 awards $191.8M
- NY 6 awards $185.7M
- PA 6 awards $111.3M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.242). How funding has trended year over year.
| 2024 | $1,722,300,004 | |
| 2025 | $1,726,864,191 | |
| 2026 est. | $99,221,272 |
FAQ
Who is eligible to apply for this R01 Clinical Trial Required grant?
Eligible applicants include researchers at U.S. research institutions, universities, medical centers, and nonprofit organizations with 501(c)(3) status or government entities. Researchers must have appropriate credentials and institutional support. Early-stage investigators, women, and underrepresented minorities are encouraged to apply.
What is the typical deadline structure and application timeline?
This grant typically has fixed annual deadlines (as noted: January 7, 2028). Applications open approximately 2-3 months before the deadline. Plan to submit well before the deadline as NIH systems often experience high traffic near cutoff times.
What types of research and interventions can be funded?
This mechanism supports comparative effectiveness research testing specific post-acute interventions (clinical, behavioral, organizational, or service-delivery models) delivered in post-acute care settings. Interventions must be testable in a rigorous clinical trial design with clearly defined primary and secondary outcomes.
How competitive is this grant mechanism?
R01 grants from NIH are highly competitive. Success rates typically range from 15-25% depending on the specific institute or center. Strong preliminary data, a clear research team, and alignment with NIH priorities increase competitiveness. Plan for multiple revision cycles to be realistic.
What is the typical funding range?
R01 grants typically provide $250,000-$500,000 per year (direct costs) for multi-year project periods (commonly 3-5 years), though actual awards vary by institute and project scope. Budget should reflect realistic costs for a rigorous clinical trial including personnel, participant incentives, and data management.
💡 Tips for applicants
- Secure strong preliminary data demonstrating the feasibility and promise of your intervention before applying. NIH reviewers prioritize applications grounded in solid foundation work, not untested concepts.
- Build a multidisciplinary team with clinical, methodological, and biostatistical expertise. Clearly define roles and demonstrate that key personnel have relevant experience in clinical trials and post-acute care settings.
- Invest time in rigorous trial design and power calculations. Justify your sample size, randomization strategy, and control condition. Weak methodology is a common rejection reason for clinical trial applications.
- Develop strong partnerships with post-acute care sites or networks early. Letters of support from facility leadership demonstrating access to patients, staff commitment, and institutional buy-in are critical for trial feasibility.
- Align your research question with current NIH priorities in post-acute care outcomes, value-based care, health equity, and aging. Review recent funded grants in your target institute to understand funding trends and expectations.
⚠️ Common mistakes
Applications often fail due to weak trial methodology—insufficient justification of sample size, unclear randomization procedures, or inadequate control conditions. Additionally, applicants frequently underestimate the complexity of recruiting and retaining participants in post-acute settings or fail to demonstrate sufficient preliminary data and institutional partnerships. Many applications lack a clear dissemination plan showing how findings will be translated into practice or policy.
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- OPEN Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional) — National Institutes of Health
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