TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 – Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 17, 2026
Can you apply?
This grant is for researchers studying genomic and phenotypic data related to heart, lung, and blood disorders. Eligible applicants include academic institutions, government agencies, nonprofits, and other research organizations with NIH funding capability. The grant supports exploratory research and method development but excludes clinical trial activities. Applicants must have institutional affiliation and relevant research infrastructure to manage large-scale omics datasets.
Not the right fit? Find grants for your organization in 5 questions →
Program description
This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases at the molecular and cellular levels. This transformation will help move TOPMed from genetic Map to Mechanism with potential applications of AI and ML tool sets where possible, enabling functional genomics research that will accelerate mechanistic personalized medicine
Who can apply
Eligible applicants
How to apply
Application links
Required documents
- SF-424 (R&R) form
- Project Narrative (5 pages)
- Specific Aims
- Research Strategy (including Significance, Innovation, and Approach)
- Budget and Budget Justification
- Biographical Sketches (key personnel)
- Institutional support letters
- Data access and management plans
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.837 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$238,898,122
-
$137,304,316
-
$117,298,604
-
$100,148,361
-
$90,428,339
-
$88,304,328
-
$83,989,552
-
$83,865,426
-
$64,483,725
-
$64,342,479
Top States by Funding
- MD 6 awards $470.1M
- NY 9 awards $442.1M
- MA 4 awards $301.0M
- CA 6 awards $201.9M
- WI 3 awards $147.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.837). How funding has trended year over year.
| 2024 | $1,654,455,334 | |
| 2025 | $1,690,039,433 |
FAQ
Who can apply for this TOPMed grant?
Academic institutions, research nonprofits, government agencies, and other organizations with NIH infrastructure. Individual researchers typically need institutional sponsorship to submit applications.
What types of research does this grant support?
Exploratory and developmental research using TOPMed data. Clinical trials are not allowed. Studies must leverage existing omics and phenotypic datasets.
What is the application deadline?
The deadline is May 8, 2028. Applications open September 22, 2025. Check NIH for any potential deadline extensions.
Is this grant competitive?
Yes. This is an NIH exploratory grant (X01 mechanism). Success requires strong preliminary data and clear scientific innovation using omics resources.
What funding amounts are typical?
X01 exploratory grants typically range from $150,000–$300,000 depending on project scope. Check the current NIH solicitation for exact budget guidelines.
💡 Tips for applicants
- Start early. Secure your institution's commitment and NIH eRA Commons access immediately after September 2025 opening.
- Ground your project in existing TOPMed datasets. Clearly explain which phenotypes and omics data you will use.
- Emphasize innovation. Show how your analysis advances beyond standard applications of TOPMed resources.
- Build a strong research team. Include biostatisticians and informatics specialists experienced with large genomic datasets.
- Address feasibility. Demonstrate access to computational resources and expertise to complete the project within the award period.
⚠️ Common mistakes
Proposing clinical trials or therapeutic interventions. This mechanism explicitly excludes clinical trial activities.
Underestimating data management complexity. Applications often fail by overlooking computational infrastructure and analysis timelines for large omics datasets.
Weak justification for using TOPMed specifically. Reviewers reject projects that don't clearly explain why this dataset is essential to answering the research question.
Similar grants
- OPEN NHLBI Program Project Applications (P01 Clinical Trials Optional) — National Institutes of Health
- OPEN NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required) — National Institutes of Health
- OPEN NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional) — National Institutes of Health
- OPEN Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) — National Institutes of Health
- OPEN Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional) — National Institutes of Health